摘要
目的探讨清燥救肺汤联合孟鲁司特钠、布地奈德治疗慢性持续期小儿哮喘痰热阻肺证的临床效果。方法选取我院收治的88例慢性持续期小儿哮喘痰热阻肺证患儿为研究对象,根据随机数字表法将其分为对照组与观察组,各44例。对照组给予孟鲁司特钠与布地奈德治疗,观察组在对照组基础上加用清燥救肺汤治疗。比较两组的治疗效果、中医证候积分、实验室指标[细胞间黏附分子-1(ICAM-1)、转化生长因子-β_(2)(TGF-β_(2))、白细胞介素-17(IL-17)]。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的喘息、咳痰、咳嗽、哮鸣音评分及ICAM-1、TGF-β_(2)、IL-17水平均低于治疗前,且观察组低于对照组(P<0.05)。结论清燥救肺汤联合孟鲁司特钠、布地奈德治疗慢性持续期小儿哮喘痰热阻肺证的效果显著,有利于降低中医证候积分,调节ICAM-1、TGF-β_(2)、IL-17水平。
Objective To investigate the clinical effect of Qingzao Jiufei decoction combined with montelukast sodium and budesonide in the treatment of phlegm-heat obstructing lung syndrome in children with chronic persistent childhood asthma. Methods A total of 88 children with chronic persistent asthma with phlegm-heat obstructing lung syndrome admitted in our hospital were selected as the research objects, and the children were divided into control group and observation group according to the random number table method, with 44 cases in each group. The control group was treated with montelukast sodium and budesonide, and the observation group was treated with Qingzao Jiufei decoction on the basis of the control group. The therapeutic effect, traditional chinese medicine syndrome score and laboratory indexes[intercellular cell adhesion molecule-1(ICAM-1), transforming growth factor-β_(2)(TGF-β_(2)), interleukin-17(IL-17)] were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group(P <0.05). After treatment, the scores of wheezing, expectoration, cough, wheezing sound and the levels of ICAM-1, TGF-β_(2)and IL-17 in the two groups were lower than those before treatment, and those in the observation group were lower than the control group(P<0.05). Conclusion Qingzao Jiufei decoction combined with montelukast sodium and budesonide in the treatment of phlegm-heat obstructing lung syndrome in children with chronic persistent asthma has remarkable effect, which is conducive to reducing the traditional chinese medicine syndrome score and regulating the levels of ICAM-1, TGF-β_(2)and IL-17.
作者
亢弘扬
陈中慧
KANG Hongyang;CHEN Zhonghui(Pediatrics Department,People's Hospital of Nanzhao County,Nanyang 474650;No.2 Ward of Pediatrics Department and Pediatric Intensive Care Unit,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473058,China)
出处
《临床医学研究与实践》
2022年第19期151-153,共3页
Clinical Research and Practice
关键词
清燥救肺汤
孟鲁司特钠
布地奈德
慢性持续期小儿哮喘
Qingzao Jiufei decoction
montelukast sodium
budesonide
chronic persistent childhood asthma
作者简介
亢弘扬(1971-),女,汉族,河南南阳人,副主任医师。研究方向:中医治疗小儿哮喘、病毒性肺炎。
