摘要
目前静脉血栓的治疗主要有抗凝、溶栓治疗、手术取栓、压力治疗等方案,其中抗凝治疗为基础治疗。近年来的抗凝药物主要有维生素K拮抗剂、普通肝素、低分子肝素及直接Ⅹa因子抑制剂等药物。抗凝药物的使用过程中如果出现异常出血、血栓复发等不良事件,将会影响患者的治疗效果与生存率。在抗凝药物使用的过程中,由于抗凝药物的种类、剂量不同,是否联合用药,出现的不良事件也不同。本文就抗凝治疗新指南中常用药物之间的对比和不良事件的研究做一综述。
At present,the treatment of venous thrombosis mainly includes anticoagulation,thrombolytic therapy,surgical thrombectomy,pressure therapy and so on.Among them,anticoagulant therapy is the basic treatment.In recent years,the anticoagulant drugs mainly include vitamin K antagonists(VKas)such as warfarin,ordinary heparin,low molecular weight heparin and directⅹA factor inhibitors such as new oral anticoagulant rivaroxaban.Adverse events such as abnormal bleeding and thrombosis recurrence during the use of anticoagulants will affect the treatment effect and survival rate of patients.In the process of anticoagulant use,adverse events are also different according to the types and doses of anticoagulants and whether they are used in combination.This article reviews the comparison of commonly used drugs and studies on adverse events in the new guidelines for anticoagulant therapy.
作者
黄韵璇
王颖
沈梦媛
HUANG Yunxuan;WANG Ying;SHEN Mengyuan(Department of respiratory and critical care medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China)
出处
《中国老年保健医学》
2022年第2期98-101,共4页
Chinese Journal of Geriatric Care
基金
云南省科技厅-昆明医科大学应用基础研究联合专项资金项目[灯盏花素调控急性肺栓塞右心室炎症趋化蛋白CINC-1和CINC-2的分子机制研究,编号:2018FE001(-239)]。
关键词
静脉血栓
抗凝治疗
低分子肝素
维生素K拮抗剂
新型口服抗凝药
出血
血栓复发
Venous thrombosis
anticoagulant therapy
low molecular weight heparin
vitamin K antagonists
new oral anticoagulants(direct oral anticoagulants)
bleeding
recurrent thrombosis
作者简介
通讯作者:王颖。
