摘要
左金丸出自元代朱丹溪《丹溪心法》,是治疗肝火犯胃证的代表方剂,也是中医反佐法的典型处方之一。笔者采用文献计量学方法,搜集整理有关左金丸的中医古籍,共获得相关文献数据729条,经一定标准检索、筛选,最终获得中医古籍57部。通过对左金丸的方剂来源、历史沿革、处方组成、功能主治、方义衍变、处方剂量及制法用法等方面进行系统分析,发现左金丸由黄连-吴茱萸(6∶1)配伍而成,主治肝火犯胃证,证见胸胁疼痛,呕吐口苦,嘈杂吞酸,舌红苔黄,脉弦数。后世医籍所记载左金丸与原方基本一致,主要治疗由肝火引起的各种病证,包括左胁痛、吞酸吐酸、筋疝痞结、脘痛、口苦脉弦、头目作痛、泄泻、淋秘、发寒热、小腹疼痛、酒湿发黄、噤口痢等,相关方义分析也鲜有争议。用法历代主要应用丸剂,与原方一致;服法多采用白汤或白术陈皮汤煎服五十丸,现代主要是水泛为丸或蒸饼为丸,温开水送服6 g,每次服用2~3 g。笔者通过挖掘整理、系统分析记载左金丸的中医古籍文献,以期为该经典名方的发展传承和开发利用提供文献依据。
Zuojinwan originated from Danxi′s Experiential Therapy(《丹溪心法》)in the Yuan dynasty.It is a representative prescription for the treatment of liver fire invading stomach syndrome,and is also one of the typical prescriptions of the anti-adjuvant method of traditional Chinese medicine(TCM).In this paper,the method of bibliometrics was used to systematically sort out the ancient books of Zuojinwan,and 729 relevant literature data were obtained.After certain retrieval and screening,57 ancient books of TCM were finally obtained.The statistics and analysis were carried out from the aspects of prescription source,historical evolution,composition,functions,evolution of prescription meaning,prescription dose,and preparation and usage of Zuojinwan.It was found that Zuojinwan was composed of Coptis chinensis rhizoma and Euodia rutaecarpa fructus in a ratio of 6∶1.It was mainly used for the treatment of liver fire invading stomach syndrome.The symptoms included pain in chest and hypochondrium,vomiting and bitter mouth,noisy acid-swallowing,red tongue coating yellow,and pulse string number.Later medical records recorded that Zuojinwan was mostly consistent with the original prescription.It mainly treated various diseases caused by liver fire,including left by liver fire,including left hypochondriac pain,swallowing acid and vomiting acid,tendon hernia and lump,epigastric pain,bitter mouth pulse string,head pain,diarrhea,gonorrhea,cold and hot,abdominal pain,alcohol wet yellowing,silence of oral dysentery and so on.There was little controversy in the analysis of relevant prescriptions.In the past dynasties,pills was mainly used,which was consistent with the original prescription.In modern times,it is mainly water flooding for pills or steamed cakes for pills,warm boiling water to serve 6 g,taking 2-3 g per time,the history is basically the same.In this paper,through the excavation,collation and systematic analysis of the ancient literature of TCM that recorded Zuojinwan,we hope to provide the literature basis for the development,inheritance and utilization of this famous classical formulas.
作者
李艳英
黄能听
韩馥蔓
杨秀伟
LI Yan-ying;HUANG Neng-ting;HAN Fu-man;YANG Xiu-wei(Beijing Increasepharm Co.Ltd.,Beijing 102200,China;Academy for Advanced Interdisciplinary Studies,School of Pharmaceutical Sciences,State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100871,China;Increasepharm(Tianjin)Institute Co.Ltd.,Tianjin 300380,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第12期39-47,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点研发计划“中医药现代化研究”重点专项(2018YFC1704500,2018YFC1704506)。
关键词
左金丸
《丹溪心法》
文献考证
主治证候
黄连
吴茱萸
经典名方
Zuojinwan
Danxi′s Experiential Therapy
literature research
indications and symptoms
Coptidis Rhizoma
Euodiae Fructus
famous classical formulas
作者简介
第一作者:李艳英,硕士,高级工程师,从事中药新药研究,Tel:010-89720100,E-mail:liyanying@ykrskj.com;通讯作者:韩馥蔓,硕士,从事中药学研究,E-mail:hanfuman@ykrskj.com;通讯作者:杨秀伟,教授,博士生导师,从事中药有效物质基础和药物代谢研究,Tel:010-82801569,E-mail:xwyang@bjmu.edu.cn。
