摘要
目的研究奥拉西坦对脑梗死恢复期伴轻度认知功能障碍患者的治疗效果及对血液流变学的影响。方法84例脑梗死恢复期伴轻度认知功能障碍患者,随机分为对照组和观察组,每组42例。对照组给予常规治疗,观察组在常规治疗的基础上加用奥拉西坦注射液治疗。比较两组患者的治疗效果及治疗前后认知功能、血液流变学变化情况。结果观察组患者的治疗总有效率95.2%明显高于对照组的81.0%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的简易精神状态检查量表(MMSE)评分(26.5±1.4)分明显高于对照组的(22.9±1.2)分,差异有统计学意义(P<0.05)。治疗后,观察组患者的全血粘度(4.88±0.57)mPa·s、血浆粘度(1.36±0.37)mPa·s、红细胞压积(35.87±2.72)%明显低于对照组的(5.86±0.53)mPa·s、(1.98±0.35)mPa·s、(39.45±2.65)%,差异有统计学意义(P<0.05)。结论应用奥拉西坦治疗脑梗死恢复期伴轻度认知功能障碍患者,能显著地改善患者的认知功能及血液流变学指标,提高患者的生活质量,具有临床推广价值。
Objective To study the effect of oxiracetam in the treatment of patients with mild cognitive dysfunction during the convalescence of cerebral infarction and its influence on hemorheology.Methods A total of 84 patients with mild cognitive dysfunction during the convalescence of cerebral infarction were randomly divided into control group and observation group,with 42 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with oxiracetam injection on the basis of conventional treatment.The therapeutic effect,cognitive function and hemorheology changes before and after treatment were compared between the two groups.Results The total effective rate in the observation group was 95.2%,which was significantly higher than 81.0%in the control group,and the difference was statistically significant(P<0.05).After treatment,the mini-mental state examination(MMSE)score of the observation group(26.5±1.4)points was significantly higher than(22.9±1.2)points of the control group,and the difference was statistically significant(P<0.05).After treatment,the whole blood viscosity(4.88±0.57)mPa·s,plasma viscosity(1.36±0.37)mPa·s,and hematocrit(35.87±2.72)%in the observation group were significantly lower than(5.86±0.53)mPa·s,(1.98±0.35)mPa·s,and(39.45±2.65)%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of oxiracetam in the treatment of patients with mild cognitive dysfunction during the convalescence of cerebral infarction can significantly improve the patients’cognitive function and hemorheology indicators,improve the life quality of patients,and has clinical promotion value.
作者
何萧伊
王晓玲
HE Xiao-yi;WANG Xiao-ling(Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,China)
出处
《中国实用医药》
2022年第9期109-111,共3页
China Practical Medicine
关键词
奥拉西坦
脑梗死恢复期
轻度认知功能障碍
血液流变学
Oxiracetam
Convalescence of cerebral infarction
Mild cognitive dysfunction
Hemorheology
