摘要
目的探讨术前外周血炎症指标对舌鳞状细胞癌(TSCC)患者预后的预测价值。方法回顾性分析2010年1月至2017年12月于郑州大学第一附属医院因TSCC行根治性切除术的210例患者的临床病理资料,应用临床诊断性能曲线确定血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)的最佳截断值。生存单因素分析应用Kaplan-Meier法和Log-rank检验,多因素分析应用Cox比例风险回归模型,基于Cox回归模型筛选的独立危险因素构建Nomogram模型。结果单因素分析显示,PLR、NLR、肿瘤分化程度、T分期、N分期和TNM分期为影响TSCC预后的危险因素(P<0.05);多因素分析显示,PLR、N分期和TNM分期为独立危险因素(P<0.05)。Nomogram模型的C指数为0.701(95%CI:0.651~0.752),校准曲线表明Nomogram模型预测无进展生存率与实际无进展生存率具有较好的一致性。结论术前外周血炎症指标对TSCC术后患者的预后可能有一定的预测作用。
Objective A study was conducted to investigate the value of preoperative peripheral blood inflammatory indicators in the prediction of tongue squamous cell carcinoma(TSCC)prognosis.Methods This retrospective analysis included 210 patients who underwent radical resection for TSCC in the Department of Oral and Maxillofacial Surgery of The First Affiliated Hospital of Zhengzhou University from January 2010 to December 2017.Receiver operating characteristic curve was conducted to determine the best cut-off values of platelet/lymphocyte ratio(PLR)and neutrophil/lymphocyte ratio(NLR).The Kaplan-Meier method and Log-rank test were conducted for univariate analysis,and the Cox proportional hazard regression model was conducted for multivariate analysis.A Nomogram model was established based on the independent risk factors,which were screened by Cox regression model.Results The univariate analysis showed that PLR,NLR,tumor differentiation,and T,N,and TNM stages were TSCC’s prognostic factors(P<0.05).Multivariate analysis showed that PLR and N and TNM stages were TSCC's independent risk factors(P<0.05).The C-index of the Nomogram was 0.701(95%CI:0.651-0.752).The calibration curve shows that the predicted survival rate of the nomogram was in good agreement with the relative survival rate.Conclusion Preoperative peripheral blood inflammatory indicators can potentially be used to predict TSCC prognosis.
作者
秦硕
李春梅
李冉
胡爽
李光辉
孙明磊
Qin Shuo;Li Chunmei;Li Ran;Hu Shuang;Li Guanghui;Sun Minglei(Dept.of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Dept.of Stomatology,Zhengzhou Peoples Hospital,Zhengzhou 450052,China)
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2022年第3期335-340,共6页
West China Journal of Stomatology
基金
河南省医学科技攻关计划省部共建项目(SBGJ202002-067)
河南省高等学校重点科研项目(22A320015)。
作者简介
秦硕,住院医师,硕士,E-mail:15621581731@163.com;通信作者:孙明磊,主任医师,博士,E-mail:mlsun@zzu.edu.cn。
