摘要
目的:分析肉毒毒素联合透明质酸凝胶治疗玫瑰痤疮的临床疗效及对皮肤屏障功能的影响。方法:选取2020年8月-2021年8月笔者科室收治的86例玫瑰痤疮患者为研究对象,随机分为使用透明质酸凝胶治疗的对照组与使用A型肉毒毒素(BTX-A)联合透明质酸凝胶(HA)治疗的联合组,每组43例。治疗后评估两组患者的治疗效果,评估治疗前、治疗4周后患者面部潮红、红斑、毛细血管扩张以及丘疹脓疱的情况,测定患者经皮水分丢失量(TEWL)以及皮肤含水量,采用皮肤病生活质量指数问卷(DLQI)评估皮肤疾病对患者生活质量的影响。结果:联合组治疗总有效率(83.72%)显著高于对照组(65.12%),差异有统计学意义(P<0.05)。治疗前,两组皮肤潮红、红斑、毛细血管扩张、丘疹脓疱评分、TEWL、皮肤含水量以及DLQI评分比较,差异均无统计学意义(P>0.05),治疗后两组皮肤潮红、红斑、毛细血管扩张、丘疹脓疱评分、以及DLQI评分较治疗前均明显下降,且联合组均低于对照组,差异有统计学意义(P<0.05),两组治疗后TEWL值均下降,但差异无统计学意义(P>0.05);治疗后,两组皮肤含水量较治疗前明显上升,其中联合组高于对照组,差异有统计学意义(P<0.05)。两组在治疗期间均未出现严重不良反应。结论:BTX-A溶液注射联合HA凝胶治疗可更有效改善玫瑰痤疮患者面部红斑、脓疱及丘疹等症状,改善皮肤屏障功能,有利于降低玫瑰痤疮导致的症状对患者生活质量带来的不良影响,疗效更佳。
Objective To analyse the clinical efficacy of botulinum toxin combined with hyaluronic acid gel in the treatment of rosacea and the effect on skin barrier function. Methods 86 patients with rosacea admitted to our hospital between August 2020 and August 2021 were selected as the subjects of this study and randomly divided into the control group(n=43) treated with hyaluronic acid gel and the joint group(n=43) treated with botulinum toxin combined with hyaluronic acid gel. The clinical outcome of the two groups was assessed after treatment. Patients were assessed for facial flushing, erythema, capillary dilation and papular pustules before treatment and after 4 weeks of treatment. Patients’ transcutaneous water loss(TEWL) as well as skin water content were measured.The Skin Disease Quality of Life Index Questionnaire(DLQI) was used to assess the impact of skin disease on patients’ quality of life. Results The total effective rate of treatment in the joint group(83.72%) was significantly higher than the control group(65.12%)(P<0.05).The differences in skin flushing,erythema, capillary dilatation, papulopustular scores, TEWL, skin water content and DLQI scores between the two groups at pre-treatment were not statistically significant(P>0.05).Skin flushing, erythema, capillary dilatation, papulopustular scores, and DLQI scores decreased significantly in both groups after treatment compared to pre-treatment, and were lower in the joint group than in the control group(P<0.05),and TEWL values decreased in both groups after treatment but were not significantly different(P>0.05). Skin water content increased significantly in both groups after treatment compared to pre-treatment, with the joint group being higher than the control group(P<0.05). No serious adverse reactions were observed in either group during the treatment period. Conclusion The combination of BTX-A solution injection and HA gel treatment is more effective in improving the symptoms of rosacea such as facial erythema and pustular papules, improving skin barrier function and helping to reduce the adverse effects of rosacea on patients’ quality of life.
作者
金星姬
王幼学
刘喜平
杨秀敏
JIN Xingji;WANG Youxue;LIU Xiping;YANG Xiumin(Department of Dermatology and Venereal Diseases,Beijing Tongren Hospital Affi liated to Capital Medical University,Beijing 100730,China)
出处
《中国美容医学》
CAS
2022年第4期21-24,共4页
Chinese Journal of Aesthetic Medicine
作者简介
第一作者:金星姬,博士研究生,主治医师,研究方向为美容皮肤病学、感染性皮肤病学。E-mail:xingkong6620@163.com。
