摘要
目的:探讨通心络胶囊联合酒石酸美托洛尔治疗老年人冠心病的临床效果。方法:选取河南科技大学第三附属医院2018年1月至2020年1月收治的老年冠心病患者78例,随机分为对照组(39例)和观察组(39例)。对照组采用酒石酸美托洛尔治疗,观察组在对照组基础上加用通心络胶囊治疗。比较两组患者的临床疗效、血管内皮功能、心功能指标及不良反应发生情况。结果:观察组患者治疗总有效率为94.87%,明显优于对照组的79.49%,差异具有统计学意义(P<0.05)。治疗前,两组患者血管内皮功能比较,差异无统计学意义(P>0.05);治疗后,观察组患者一氧化氮(NO)水平、肱动脉内皮依赖性血管舒张功能(FMD)高于对照组,内皮素–1(ET–1)水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者心功能指标比较,差异无统计学意义(P>0.05);治疗后,观察组患者左心室射血分数(LVEF)、心输出量(CO)高于对照组,左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:通心络胶囊联合酒石酸美托络尔可改善老年冠心病患者血管内皮功能,增加心肌供血量,加快心功能恢复,安全性较好。
Objective To investigate the clinical effect of tongxinluo capsule combined with metoprolol tartrate in the treatment of elderly coronary heart disease.Methods A total of 78 elderly patients with coronary heart disease admitted to the Third Affiliated Hospital of Henan University of Science and Technology from January 2018 to January 2020 were selected and randomly divided into control group and observation group,with 39 cases in each group.The control group was treated with metoprolol tartrate,and the observation group was additionally treated with tongxinluo capsule on the basis of the control group.The clinical efficacy,vascular endothelial function,cardiac function indexes and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.87%,significantly better than 79.49%of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in vascular endothelial function between the two groups(P>0.05).After treatment,the level of nitric oxide(NO)and flow-mediated dilatation(FMD)in the observation group were higher than those in the control group,and the level of endothelin-1(ET-1)was lower than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in cardiac function indexes between the two groups(P>0.05);After treatment,left ventricular ejection fraction(LVEF)and cardiac output(CO)in the observation group were higher than those in the control group,left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tongxinluo capsule combined with metolool tartrate can improve vascular endothelial function,increase myocardial blood supply and accelerate cardiac function recovery in elderly patients with coronary heart disease,with good safety.
作者
朱晓丽
张亮
ZHU Xiao-li;ZHANG Liang(The Third Affiliated Hospital of Henan University of Science and Technology,Henan Luoyang 471003)
出处
《深圳中西医结合杂志》
2022年第3期38-41,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
冠心病
通心络胶囊
酒石酸美托洛尔
老年人
Coronary heart disease
Tongxinluo capsule
Metoprolol tartrate
Elderly
作者简介
朱晓丽,女,主治医师,主要研究方向是心血管内科疾病。
