摘要
目的:探讨沙库巴曲缬沙坦对顽固性心力衰竭合并动脉粥样硬化患者心功能及血管内皮功能的影响。方法:选取2018年2月~2021年2月期间本院收治的顽固性心力衰竭合并动脉粥样硬化患者作为研究对象,根据用药不同分为对照组(n=46)和观察组(n=44)。对照组给予常规治疗,观察组在对照组基础上给予沙库巴曲缬沙坦治疗,比较两组临床疗效、治疗前后的心功能及血管内皮功能变化。结果:观察组治疗总有效率高于对照组(P<0.05);治疗后,观察组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)低于对照组,而左室射血分数(LVEF)高于对照组(P<0.05);治疗后,观察组血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)水平低于对照组,血清一氧化氮(NO)水平高于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论:沙库巴曲缬沙坦治疗顽固性心力衰竭合并动脉粥样硬化患者效果显著,有利于心功能和血管内皮功能的恢复,安全性较高。
Objective: To investigate the effects of sacubitril valsartan on cardiac function and vascular endothelial function in patients with refractory heart failure and atherosclerosis. Methods: Patients with refractory heart failure and atherosclerosis treated in our hospital from February 2018 to February 2021were selected as the research subjects and divided into control group and observation group according to different medication use. The control group(n=46) was given conventional treatment, and observation group(n=44) was given sacubitril valsartan based on the control group. The clinical efficacy, changes of cardiac function and vascular endothelial function before and after treatment were compared between the two groups.Results: The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment, the left ventricular end systolic diameter(LVESD) and left ventricular end diastolic diameter(LVEDD) of the observation group were lower than those of the control group, whereas the left ventricular ejection fraction(LVEF) was higher than that of the control group(P<0.05). After treatment,plasma endothelin-1(ET-1) and calcitonin gene-related peptide(CGRP) were lower than that of the control group, and serum nitric oxide(NO) in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion: Sacubitril valsartan was highly effective in the treatment of patients with refractory heart failure and atherosclerosis, which is beneficial to the recovery of cardiac function and vascular endothelial function with high safety.
作者
屠淑敏
张卫平
罗常月
TU Shu-min;ZHANG Wei-ping;LUO Chang-yue(The First People’s Hospital of Shangqiu,Shangqiu 476100,China)
出处
《中国合理用药探索》
2022年第3期62-65,共4页
Chinese Journal of Rational Drug Use
基金
2020年河南省医学科技攻关计划联合共建项目(LHJ20200925)。
关键词
沙库巴曲缬沙坦
顽固性心力衰竭
动脉粥样硬化
心功能
血管内皮功能
sacubitril valsartan
refractory heart failure
atherosclerosis
cardiac function
vascular endothelial function
作者简介
屠淑敏,女,副主任医师,专业方向:急诊急救。E-mail:zhangjing336@163.com。
