摘要
报告1例以全身红斑、丘疹伴发热为首发症状的血管免疫母细胞性T细胞淋巴瘤。患者男,61岁。因全身红斑、丘疹伴瘙痒和发热20d,加重2d入院。淋巴结组织病理检查:淋巴结结构破坏,淋巴滤泡消失,高内皮血管增生,异形淋巴样细胞浸润。免疫组化:肿瘤细胞CD3、CD5、CXC趋化因子配体(CXCL)13、CD2、CD7及CD4均阳性,CD 10(少许细胞)及增殖核抗原(Ki-67)(约30%)阳性,CD20及B细胞特异性转录因子(PAX)5示B细胞局灶阳性,CD21示不规则滤泡树突细胞网,EB病毒编码的RNA(EBER)示少量大细胞阳性。根据患者皮损、淋巴结组织病理及免疫组化检查结果,诊断为血管免疫母细胞性T细胞淋巴瘤。
A case of angioimmunoblastic T cell lymphoma with erythema, papules and fever as the first symptoms was reported. The patient, a 61-year-old man with erythema, papules, itching and fever for more than 20 days, was admitted to hospital because symptoms had been worsening for 2 days. Histopathological examination of lymph nodes revealed destruction of lymph node structure, disappearance of lymphatic follicles, high endothelial vascular proliferation, and infiltration of atypical lymphocytes. Immunohistochemistry showed tumor cells were positive for CD3, CD5, C-X-C chemokine ligand(CXCL)13, CD2,CD7, CD4, CD10(a few cells) and proliferating nuclear antigen(Ki-67)(about 30%). B cells were focal positive for CD20 and B cell specific transcription factor(PAX)5. CD21 showed irregular follicular dendritic cell network. A small number of large cells were positive for Epstein-Barr virus-encoded RNA(EBER). According to the characteristics of skin lesions, histopatho logical examination of lymph nodes, and immunohistochemistry, the case was diagnosed as angioimmunoblastic T cell lymphoma.
作者
张淑兰
张颖鹏
彭亚婷
李春明
刘藕根
ZHANG Shu-lan;ZHANG Ying-peng;PENG Ya-ting;LI Chun-ming;LIU Ou-gen(Department of Dermatology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2021年第11期669-672,共4页
Journal of Clinical Dermatology
作者简介
通信作者:张颖鹏,E-mail:48935513@qq.com。
