摘要
目的:分析乳腺炎患者的感染状况及白细胞(white blood cells,WBC)、C反应蛋白(C-reactive protein,CRP)、血清淀粉样蛋白A(serum amyloid A,SAA)、降钙素原(procalcitonin,PCT)水平,探讨上述指标在乳腺炎患者中的诊断价值。方法:选取2018年1月-2020年8月南方医科大学附属南海区人民医院收治住院的乳腺炎患者50例作为研究对象,另选取同期在该院进行乳腺筛查的50例健康志愿者作为对照。经穿刺抽取所有乳腺炎患者的脓液进行分离培养,分析其病原菌分布情况;同时分析比较乳腺炎患者用药前与健康对照组的WBC、CRP、PCT、SAA水平。结果:50例乳腺炎患者送检的标本中有16例分离出病原菌,阳性率为32%,且以金黄色葡萄球菌为主。与对照组相比,乳腺炎患者的CRP、SAA、PCT水平均显著升高,差异有统计学意义(P<0.05);与非哺乳期乳腺炎组对比,哺乳期乳腺炎组的CRP、PCT水平升高,差异有统计学意义(P<0.05);与肉芽肿性乳腺炎组相比,浆细胞性乳腺炎组的WBC值更高,差异有统计学意义(P<0.05);与浆细胞性乳腺炎组对比,肉芽肿性乳腺炎组CRP与SAA水平更高,差异有统计学意义(P<0.05)。结论:病原菌培养及药敏试验是乳腺炎抗感染治疗的重要依据,但其阳性率不高,CRP、SAA、PCT的检测有助于早期诊断乳腺炎,CRP、PCT有助于鉴别病因,联合检测上述治疗指标可辅助诊断鉴别乳腺炎并拟定治疗方案。
Objective:To analyze the infection status and levels of white blood cells(WBC),C-reactive protein(CRP),serum amyloid A(SAA)and procalcitonin(PCT)in patients with mastitis,and to explore the diagnostic value of these indexes in patients with mastitis.Methods:A total of 50 patients with mastitis admitted to the Nanhai District People's Hospital Affiliated to Southern Medical University from January 2018 to August 2020 were selected as subjects,and 50 healthy volunteers who underwent breast screening in the hospital during the same period were selected as controls.The pus of all mastitis patients was isolated and cultured by puncture,and the distribution of pathogens was analyzed.At the same time,the levels of WBC,CRP,PCT and SAA in patients with mastitis before medication and healthy control group were analyzed and compared.Results:A total of 16 cases were detected from the specimens submitted by 50 patients with mastitis,with a detection rate of 32%,and staphylococcus aureus was the main strain.Compared with the control group,the levels of CRP,SAA and PCT in patients with mastitis were significantly increased,and the difference was statistically significant(P<0.05).Compared with the non-lactating mastitis group,the levels of CRP and PCT in the lactation mastitis group were increased,and the differences were statistically significant(P<0.05).Compared with granulomatous mastitis group,the level of WBC in plasma cell mastitis group was higher,and the difference was statistically significant(P<0.05).Compared with plasma cell mastitis group,the levels of CRP and SAA in granulomatous mastitis group were higher,and the difference was statistically significant(P<0.05).Conclusion:Pathogenic bacteria culture and drug sensitivity test is an important basis for the anti-infective treatment of mastitis,however,its positive rate is not ideal.CRP,SAA,and PCT are favorable for the early diagnosis of mastitis,meanwhile CRP and PCT are helpful to identify the cause.The combined detection of these biomarkers may assist in the diagnosis and identification of mastitis and the formulation of treatment plans.
作者
严国标
陈明
YAN Guobiao;CHEN Ming(Nanhai District People's Hospital Affiliated to Southern Medical University,Foshan 528000,China)
出处
《包头医学院学报》
CAS
2022年第4期9-12,22,共5页
Journal of Baotou Medical College
作者简介
通讯作者:严国标。
