摘要
瘢痕疙瘩的发病原因及具体机制尚不明确,目前认为瘢痕疙瘩的形成是多种因素共同作用的结果,成纤维细胞外因素在瘢痕疙瘩形成中发挥着重要作用;糖代谢变化是一个新的研究方向;转化生长因子(TGF)-β1及与其相关的TGF-β1/Smad信号通路被认为与瘢痕疙瘩形成的关系最为密切。该文就瘢痕疙瘩成纤维细胞外因素、细胞糖代谢、细胞信号通路的最新研究进展做一综述。
The etiology and pathogenesis of keloid are still not clear.It is believed that the formation of keloid is due to the joint action of many factors,during which process the external factor of fibroblast play an important role.Reprogramming of glucose metabolism in keloid fibroblasts is a new research direction.TGF-β1 and its related TGF-β1/Smad signalling pathway are considered to be the most closely related to the formation of keloid.This article reviews the research progress on extracellular factors,glucose metabolism and signaling pathways of keloids.
作者
苏治国
范金财
刘立强
焦虎
陈红波
陈弋华
Su Zhiguo;Fan Jincai;Liu Liqiang;Jiao Hu;Chen Hongbo;Chen Yihua(Ninth Department of Plastic Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China)
出处
《中华整形外科杂志》
CSCD
2022年第2期228-231,共4页
Chinese Journal of Plastic Surgery
关键词
瘢痕疙瘩
发病机制
炎症
糖代谢
信号通路
Keloid
Pathogenesis
Inflammation
Glucose metabolism
Signaling pathway
作者简介
通信作者:焦虎,Email:jiaohu2006@126.com。
