摘要
STAT3是信号转导及转录激活因子家族成员,在肝癌等慢性炎症相关性肿瘤中异常激活。作为肝癌炎症微环境中的关键信号分子,STAT3不仅参与肝癌发生过程中的“炎癌转化”,而且通过多种方式促进肝癌进展中癌细胞的增殖、侵袭与转移,是一个潜在的肝癌治疗靶标。综述了近几年STAT3与肝癌关系的新进展。
STAT3,a member of the signal transducer and activator of transcription family,is abnormally activated in chronic inflammation-related tumors including liver cancer.As a key signal molecule in the microenvironment of liver cancer and inflammation,STAT3 not only participates in the inflammation-cancer transformation during the development of liver cancer,but also promotes the proliferation,invasion,and metastasis of hepatoma cells through many ways,and therefore,it may be a potential target for the treatment of liver cancer.This article reviews the recent advances in the association between STAT3 and liver cancer.
作者
音金萍
岳紫晨
卓少元
YIN Jinping;YUE Zichen;ZHUO Shaoyuan(School of Basic Medical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第4期948-952,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金地区科学基金项目(81660775,81860824)。
关键词
肝肿瘤
STAT3转录因子
炎症
liver neoplasms
STAT3 transcription factor
inflammation
作者简介
音金萍(1995-),女,主要从事肝癌的中医药防治研究;通讯作者:卓少元,电子信箱:sherwin_zhuo@126.com。
