摘要
【目的】以传统T1(T1-FSPGR)成像为标准,对比研究基于集成磁共振成像(SyMRI)对正常青年及儿童的脑组织体积分割测量的一致性。【方法】前瞻性收集38例6~13岁健康儿童志愿者及30例22~26岁健康青年志愿者的T1-FSPGR及SyMRI图像,分别用FreeSurfer软件及Synthetic MR软件处理并计算得到脑内的总灰质体积(GMV)、总白质体积(WMV)、脑实质体积(BPV)及颅内体积(ICV)。用配对t检验、Pearson相关性分析及ICC一致性检验分别评价GMV、WMV、BPV、ICV四个参数在两种不同方法中得到数值的相关性。【结果】在儿童组及青年组中通过配对t检验显示两种方法所得的GMV、WMV、BPV、ICV的值虽具有差异(P<0.05),但均具有较好的相关性(Pearson相关分析儿童组中r值分别为0.691、0.577、0.938、0.796,P<0.001;青年组中r值分别为0.657、0.623、0.933、0.881,P<0.001)及一致性[儿童组ICC95%CI分别为0.816(0.647,0.905),0.732(0.484,0.861),0.968(0.938,0.983),及0.880(0.770,0.938),青年组ICC95%CI分别为0.751(0.476,0.881),0.760(0.496,0.886),0.962(0.920,0.982),及0.936(0.866,0.970)]。【结论】在儿童组及青年组中,基于SyMRI及传统T1-FSPGR图像的脑分割结果虽由于分割原理及具体定义不同而具有差异,但两组数据具有良好的相关性及一致性,表明基于SyMRI的脑组织分割测量方法具有良好的临床和科研运用前景。
【Objective】To investigate the consistency of the brain structure volume estimation based on Synthetic MRI(SyMRI)and T1-FSPGR images in healthy children and youths.【Methods】We prospectively collected the brain SyMRI and T1-FSPGR images of 38 healthy children with age range of 6~13 years old and 30 healthy youths with age range of 22~26 years old.The Sythetic MR software and FreeSurfer software were used to measure the total gray matter volume(GMV),total white matter volume(WMV),brain parenchyma volume(BPV)and intracranial volume(ICV)based on SyMRI and T1-FSPGR images respectively.Paired t test,Pearson’s correlation analysis and interclass correlation coefficient(ICC)were used to evaluate the association between SyMRI and T1 derived measurements.【Results】The volumes estimated by two methods in two groups showed differences in paired t test(P<0.05).Nevertheless,both in children and youths,the measurements of GMV,WMV,BPV and ICV all showed noticeable correlation and consistency between the two brain vol⁃ume estimation methods[r values are 0.691,10.577,0.938,0.796 in children group and 0.657,0.623,0.933,0.881 in adult group,P<0.001;ICC95%CIs are 0.816(0.647,0.905),0.732(0.484,0.861),0.968(0.938,0.983)and 0.880(0.770,0.938]in children group and 0.751(0.476,0.881),0.760(0.496,0.886),0.962(0.920,0.982),and 0.936(0.866,0.970)in youth group].【Conclusions】The brain segmentation and volume estimation based on SyMRI can acquire the measurements which have statistical difference but powerful association with that acquired from T1-FSPGR images,which suggests this new method have a good prospect for clinical use and scientific research.
作者
戴艳
陈颖茜
苏舒
钱龙
吴柳晖
张洪宇
范淼
杨智云
DAI Yan;CHEN Ying-qian;SU Shu;QIAN Long;WU Liu-hui;ZHANG Hong-yu;FAN Miao;YANG Zhi-yun(Department of Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Department of Pediatrics,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;MR Research,GE Healthcare,Beijing100000,China)
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2022年第2期268-275,共8页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(82001439)
广东省医学科研基金(A2020327)。
关键词
磁共振成像
灰质
白质
儿童
青年
MRI
gray matter
white matter
children
youth
作者简介
戴艳,学士,研究方向:儿童磁共振,E-mail:617736918@qq.com;通信作者:张洪宇,E-mail:drzhy@126.com。
