摘要
目的:对经麸炒木香炮制的不同批次的中药材木香进行实验研究,测定不同批次和不同麸炒条件下木香药材中木香烃内酯和去氢木香内酯的含量,确定一种合理可行且较为优质的炮制工艺,为建立麸炒木香的炮制标准及木香麸炒品的生产提供参考。方法:对麸炒木香进行薄层层析法(TLC)鉴别;利用高效液相色谱(HPLC)法对两种主要成分——木香烃内酯和去氢木香内酯进行含量测定。结果:不同的麸炒木香炮制方法直接影响木香烃内酯和去氢木香内酯的含量:木香药材与麸皮投药比在10∶1~6.6∶1范围内可行,其中,投药比为6.6∶1时各项成分含量较高;炒药时间在6~8 min为宜,其中,麸炒6 min时木香烃内酯的含量较高,麸炒8 min时去氢木香内酯含量较高。结论:本研究建立的炮制工艺简单可行、准确、重现性好,可用于控制麸炒木香的质量。
Objective:To determine the content of costunolide and dehydrocostus lactone in different batches of aucklandiae radix stir fried with bran and under different bran fry conditions,and to establish a reasonable,feasible and relatively high-quality processing technology,so as to provide reference for establishing the processing standard of aucklandiae radix stir fried with bran,and the production of aucklandiae radix stir fried with bran.Methods:Thin layer chromatography(TLC)was used to identify aucklandiae radix stir fried with bran.The content of two main components,costunolide and dehydrocostus lacton were determined by high performance liquid chromatography(HPLC).Results:Different process method directly affected the content of costunolide and dehydrocostus lacton.The dosing ratio of aucklandiae radix to bran was feasible in the range of 10∶1-6.6∶1,and when the dosing ratio was 6.6∶1,the content of costunolide and dehydrocostus lacton was higher.Stir-frying time in 6-8 min was appropriate,the content of costunolide was higher when fried for 6 min,and the content of dehydrocostus lactone was higher when fried for 8 min.Conclusion:The established processing method is simple,feasible,accurate and reproducible,and can be used to control the quality of aucklandiae radix stir fried with bran.
作者
谭洪泉
马彧
赵磊
TAN Hongquan;MA Yu;ZHAO Lei(Siping Institute for Food and Drug Control, Jilin Siping 136000, China;School of Pharmacy, Changchun University of Traditional Chinese Medicine, Jilin Changchun 130117, China)
出处
《中国医药导刊》
2022年第2期179-183,共5页
Chinese Journal of Medicinal Guide
作者简介
谭洪泉,男,副主任药师,研究方向:色谱与光谱,E-mail:16048034@qq.com;通讯作者:赵磊,男,在读博士研究生,副主任药师,研究方向:中药质量控制研究,E-mail:zhaolei0433@sina.com;通讯作者:马彧,男,主任药师,研究方向:药品质量管理,E-mail:346819014@qq.com。
