摘要
目的研究头孢地尼联合奥硝唑治疗盆腔炎的临床效果。方法选取78例盆腔炎患者作为研究对象,按随机数字表法分为对照组和观察组,各39例。对照组口服奥硝唑治疗,观察组口服奥硝唑联合头孢地尼治疗。比较两组治疗效果、治疗前后炎症因子[白细胞介素-1(IL-1)、C反应蛋白(CRP)]水平、治疗前后血液流变学指标(血浆粘度、红细胞压积)、不良反应发生情况。结果观察组治疗总有效率为94.87%,高于对照组的74.36%,差异具有统计学意义(P<0.05)。治疗后,两组IL-1、CRP水平均较治疗前降低,观察组IL-1(20.74±7.25)pg/ml、CRP(11.26±4.53)mg/L均低于对照组的(34.12±12.06)pg/ml、(17.06±4.55)mg/L,差异具有统计学意义(P<0.05)。治疗后,两组血浆粘度、红细胞压积均较治疗前降低,观察组血浆粘度(1.11±0.21)mPa·s、红细胞压积(0.33±0.04)均低于对照组的(1.58±0.22)mPa·s、(0.45±0.06),差异具有统计学意义(P<0.05)。观察组不良反应发生率2.56%低于对照组的23.08%,差异具有统计学意义(P<0.05)。结论头孢地尼联合奥硝唑治疗盆腔炎,可有效降低炎症因子水平,改善血液流变学,不良反应少,可确保治疗安全性。
Objective To study the clinical effect of cefdinir combined with ornidazole in the treatment of pelvic inflammatory disease.Methods A total of 78 patients with pelvic inflammatory disease as the research subjects were divided into the control group and the observation group according to random numerical table,with 39 cases in each group.The control group was treated with ornidazole,and the observation group was treated with ornidazole and cefdinir.Both groups were compared in terms of therapeutic effects,the levels of inflammatory factors[interleukin-1(IL-1),C-reactive protein(CRP)]and hemorheological indicators(plasma viscosity,hematocrit)before and after treatment,and occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was 94.87%,which was higher than 74.36%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-1 and CRP in the two groups were lower than those of this group before treatment;the IL-1(20.74±7.25)pg/ml and CRP(11.26±4.53)mg/L in the observation group were lower than(34.12±12.06)pg/ml and(17.06±4.55)mg/L in the control group;all the differences were statistically significant(P<0.05).After treatment,the plasma viscosity and hematocrit of the two groups were lower than those of this group before treatment;the plasma viscosity(1.11±0.21)mPa·s and hematocrit(0.33±0.04)of the observation group were lower than(1.58±0.22)mPa·s and(0.45±0.06)of the control group;all the differences were statistically significant(P<0.05).The incidence of adverse reactions 2.56%in the observation group was lower than 23.08%in the control group,and the difference was statistically significant(P<0.05).Conclusion Cefdinir combined with ornidazole in the treatment of pelvic inflammatory disease can effectively reduce the level of inflammatory factors,improve hemorheology,reduce adverse reactions,and ensure the safety of treatment.
作者
李玲
LI Ling(Zhuanghe Hospital of Traditional Chinese Medicine,Zhuanghe 116400,China)
出处
《中国现代药物应用》
2022年第3期171-173,共3页
Chinese Journal of Modern Drug Application
关键词
头孢地尼
奥硝唑
盆腔炎
血液流变学
治疗效果
Cefdinir
Ornidazole
Pelvic inflammatory disease
Hemorheology
Therapeutic effect
