摘要
目的分析红细胞沉降率(ESR)、乳酸脱氢酶(LDH)、白介素细胞2(IL-2)检测在高血压性脑出血术后发生颅内感染的诊断价值。方法收集2017年3月至2021年1月于平顶山市第二人民医院行手术治疗的126例高血压性脑出血患者,探究ESR、LDH、IL-2与高血压性脑出血术后发生颅内感染的关系,并分析ESR、LDH、IL-2对术后发生颅内感染的诊断价值。结果126例患者术后感染37例(感染组),术后未感染89例(未感染组),两组在年龄、引流管置留时间、ESR、LDH、IL-2、基础疾病中差异均有统计学意义(P<0.05),在性别中比较差异无统计学意义(P>0.05)。将单因素中有统计学意义的因素代入条件Logistic回归模型分析中发现,年龄、引流管置留时间、ESR、LDH、IL-2、基础疾病与血压脑出血术后发生颅内感染存在相关性(P<0.05)。依据ROC曲线可知,ESR+LDH+IL-2联合检测对高血压性脑出血术后发生颅内感染诊断敏感度和特异度分别为87.70%、60.90%、AUC=0.811(95%CI:0.718~0.903),明显高于三者单独诊断(P<0.05)。结论高血压性脑出血术后颅内感染时ESR、LDH、IL-2均升高,与术后颅内感染密切相关,三者联合检测可减少误诊、漏诊率,为术后颅内感染诊断提供重要参考依据。
Objective To analyze the diagnostic value of erythrocyte sedimentation rate(ESR),lactate dehydrogenase(LDH),interleukin-2(IL-2)detection in patients with intracranial infection after hypertensive intracerebral hemorrhage.Methods A total of 126 patients with hypertensive cerebral hemorrhage who underwent surgical treatment in the Second People’s Hospital of Pingdingshan city from March 2017 to January2021 were selected.The relationship between the ESR、LDH、IL-2 and intracranial infection after hypertensive intracerebral hemorrhage was explored.The diagnostic value of ESR,LDH,IL-2 for intracranial infection after hypertensive intracerebral hemorrhage was analyzed.Results Among the 126 patients,37 were infected after surgery(infected group),and 89 were uninfected after surgery(non-infected group).There were significant differences in age,drainage tube retention time,ESR,LDH,IL-2,and underlying diseases between the two groups(P<0.05),and there was no statistically significant difference in gender(P>0.05).After Substituting the factors with statistical significance into the conditional Logistic regression model analysis,and it was found that age,drainage tube retention time,ESR,LDH,IL-2,and underlying diseases were related to intracranial infection after hypertensive intracerebral hemorrhage(P<0.05).According to the ROC curve,the sensitivity and specificity of the combined detection of ESR+LDH+IL-2 for the diagnosis of intracranial infection after hypertensive intracerebral hemorrhage were 87.70%,60.90%,and AUC=0.811(95%CI:0.718~0.903),which was significantly higher than the diagnosis of ESR,LDH,and IL-2 alone(P<0.05).Conclusion ESR,LDH,and IL-2 all increase during postoperative intracranial infection in patients with hypertensive intracerebral hemorrhage,which are closely related to postoperative intracranial infection.The combined detection of the three can reduce the rate of misdiagnosis and missed diagnosis and provide information for the diagnosis of postoperative intracranial infection.
作者
李润峰
王万卿
李万军
李跃鹤
LI Runfeng;WANG Wanqing;LI Wanjun;LI Yuehe(Department of Neurosurgery,the Second People's Hospital of Pingdingshan City,Pingdingshan,Henan,China,467000)
出处
《分子诊断与治疗杂志》
2022年第1期112-115,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划联合共建项目(LHGJ20170418)。
作者简介
通信作者:李润峰,E⁃mail:lrf15137571928@163.com。
