摘要
目的:探究西黄丸联合TP化疗方案对晚期卵巢癌患者肿瘤标志物及Th1/Th2细胞因子的影响。方法:研究对象为2019年9月-2021年3月赣州市肿瘤医院收治的70例晚期卵巢上皮性癌术后接受化疗患者,按照随机数字表法分为两组,每组35例。对照组行紫杉醇联合铂类药物(TP)化疗,3周为1个化疗周期,连续治疗4个周期;观察组在对照组治疗基础上加以西黄丸治疗,连续用药3个月。两组化疗后均行肿瘤细胞减灭术。比较两组治疗前、疗程结束血清Th1/Th2细胞因子水平[Th1细胞因子:γ-干扰素(IFN-γ)、白细胞介素-2(IL-2),Th2细胞因子:白细胞介素-6(IL-6)、白细胞介素-4(IL-4)]、血清癌胚抗原(CEA)、糖类抗原199(CA199)、CA153水平以及化疗效果和不良反应。结果:治疗前,两组血清Th1/Th2细胞因子、CEA、CA199、CA153水平比较,差异均无统计学意义(P>0.05)。疗程结束,观察组血清CEA、CA199、CA153、IFN-γ、IL-2水平均显著低于对照组,IL-6、IL-4水平均显著高于对照组,差异均有统计学意义(P<0.05)。观察组和对照组总有效率分别为94.29%(33/35)、74.29%(26/35),两组比较差异有统计学意义(P<0.05)。观察组神经毒性发生率低于对照组(P<0.05),但两组骨髓抑制和肝肾功能损伤发生率比较,差异均无统计学意义(P>0.05)。结论:西黄丸联合TP化疗可显著提高晚期卵巢癌患者的化疗效果,增强免疫功能,减少化疗不良反应,降低血清肿瘤标志物水平,值得借鉴于临床。
Objective:To explore the effect of Xihuang Pills combined with TP chemotherapy on tumor markers and Th1/Th2 cytokines in patients with advanced ovarian cancer.Method:The subjects of the study were 70 patients with advanced epithelial ovarian cancer who received chemotherapy after surgery in Ganzhou Cancer Hospital from September 2019 to March 2021,they were divided into two groups according to the random number table method,35 cases in each group.The control group was treated with Paclitaxel combined with Platinum-based drugs(TP)chemotherapy,3 weeks as a chemotherapy cycle,and 4 cycles of continuous treatment,the observation group was treated with Xihuang Pills for 3 months on the basis of the control group,two groups underwent cytoreductive surgery after chemotherapy.The serum Th1/Th2 cytokines levels[Th1 cytokine:interferon-γ(IFN-γ),interleukin-2(IL-2),and Th2 cytokine:interleukin-6(IL-6),interleukin-4(IL-4)],serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),CA153 levels before and after treatment,and chemotherapy effects and adverse reactions were compared between two groups.Result:There were no significant differences in the levels of serum Th1/Th2 cytokines,CEA,CA199,CA153 between two groups before treatment(P>0.05).At the end of the treatment period,the levels of serum CEA,CA199,CA153 and IFN-γand IL-2 of the observation group were significantly lower than those of the control group,and the levels of IL-6 and IL-4 were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The total effective rates in the observation group and the control group were 94.29%(33/35)and 74.29%(26/35)respectively,the difference between two groups was statistically significant(P<0.05).The incidence of neurotoxicity in the observation group was lower than that in the control group(P<0.05),but there were no significant differences in the incidence of bone marrow suppression and liver and kidney function injury between two groups(P>0.05).Conclusion:Xihuang Pills combined with TP chemotherapy can significantly improve the chemotherapy effect of patients with advanced ovarian cancer,enhance immune function,reduce adverse reactions to chemotherapy,and reduce serum tumor markers levels,it is worth learning from the clinic.
作者
程细云
易琰斐
申昌梅
余瑛
廖振蓉
王琪
CHENG Xiyun;YI Yanfei;SHEN Changmei;YU Ying;LIAO Zhenrong;WANG Qi(Ganzhou Cancer Hospital,Jiangxi Province,Ganzhou 341000,China)
出处
《中国医学创新》
CAS
2021年第36期76-80,共5页
Medical Innovation of China
基金
江西省中医药管理局科技计划课题(2020A0045)。
作者简介
通信作者:程细云。
