摘要
目的:观察西黄丸联合化疗治疗中晚期肝癌的临床近期和1年随访疗效。方法:选择2003年3月至2005年3月就诊于本科的中晚期肝癌患者共80例,随机分为治疗组与对照组各40例。对照组予介入化疗,给予顺铂30mg局部给药。治疗组在对照组介入化疗方案基础上加用西黄丸,每次3g,每日2次。结果:两组均无CR病例,对照组PR14例,SD16例,PD10例;临床受益率为35.00%;中位生存期7个月,疾病进展时间3.2个月,1年生存期为40.00%(16/40)。治疗组PR17例,SD16例,PD7例;临床受益率42.50%;中位生存期9个月,疾病进展时间5.4个月,1年生存期为45.00%(18/40)。两组比较差异有显著性。结论:西黄丸联合介入化疗治疗中晚期原发性肝癌疗效优于单纯介入化疗,能够提高1年生存期,提高患者的生存质量。
Objective：To evaluate the therapeutical effects of Xihuang Pills with intraarterial intervention chemotherapy on advanced primary hepatic carcinoma for the near term and one year follow-up. Methods：80 cases of advanced primary hepatic carcinoma in our hospital from March 2003 to March 2005 were divided randomly into treatment group （40 cases） and control group （40 cases）.Control group were treated with intraarterial intervention chemotherapy （Intraarterial DDP 30mg）.Treatment group were treated with intraarterial intervention chemotherapy （Intraarterial DDP 30mg） and Xihuang Pills （3.0g,BID）.Results：There were no CR cases in both groups. There were 14 CR cases,16 SD cases,10 PD cases in control group.The clinical benefi tial response （CBR） of control group was 35.00%.The median TTP and MST of treatment group were 3.2 months and 7.0 months. The one-year survival rate of control group was 40.00% （16/40）.There were 17 CR cases,16 SD cases,7 PD cases in treatment group. The clinical benefi tial response （CBR） of treatment group was 42.50%.The median TTP and MST of treatment group were 5.4 months and 9.0 months.The one-year survival rate of treatment group was 45.00% （18/40）.There was a signifi cant difference between the treatment group and the control group. Conclusions：The therapeutical effects of Xihuang Pills with intraarterial intervention chemotherapy on advanced hepatocellular carcinoma was better than the intraarterial intervention chemotherapy,which can improve the one-year survival rate and life quality.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2010年第6期947-948,共2页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
原发性肝癌
介入化疗
近期疗效
生存期
Primary hepatocarcinoma
Intraarterial intervention chemotherapy
Short term effect
Survival time
作者简介
通讯作者：高清泽，河北医科大学第二医院肿瘤外科，邮编：050000，电话：0311-66002312，E-mail：gaoqingze@yeah．net
