摘要
目的探讨抗苗勒管激素(AMH)、血脂水平和卵巢超声检查指标与多囊卵巢综合征(PCOS)患者子宫内膜厚度的相关性。方法选取2020年3月至2021年6月河南省中医院/河南中医药大学第二附属医院收治的PCOS患者134例作为研究组,选取同期在河南省中医院/河南中医药大学第二附属医院体检的女性健康体检者100例作为对照组。检测2组研究对象AMH、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平,采用B超检查2组研究对象子宫内膜厚度、卵巢体积、卵泡大小等,并分析子宫内膜厚度与AMH、血脂水平、卵巢超声检查指标的相关性。结果研究组患者AMH、TC、TG、LDL-C、子宫内膜厚度、卵泡大小均明显高于对照组,HDL-C水平明显低于对照组,差异均有统计学意义(P<0.05)。PCOS患者子宫内膜厚度与AMH、TC、TG、LDL-C、卵泡大小呈正相关(P<0.05),与HDL-C呈负相关(P<0.05)。结论PCOS患者子宫内膜厚度与AMH、血脂水平、卵巢超声检查指标密切相关,提示临床医师在进行治疗的同时应密切监测AMH、血脂水平和卵巢超声检查指标,以提高疗效。
Objective To investigate the correlation of anti-Mullerian hormone(AMH),blood lipid level and ovarian ultrasound index with endometrial thickness in patients with polycystic ovary syndrome(PCOS).Methods A total of 134 patients with PCOS admitted to Henan Province Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,hospital from March 2020 to June 2021 were retrospectively collected as the study group,while 100 healthy female patients in the physical examination center during the same period were collected as the control group.The levels of AMH,cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C)in two groups were detected.B-ultrasound was used to examined the endometrial thickness,ovarian volume and follicle size.The correlation between endometrial thickness and AMH,lipid level and ovarian ultrasound indexes were analyzed.Results The AMH,TC,TG,LDL-C,endometrial thickness and follicle size in the study group were significantly higher than those in the control group,while the HDL-C level was significantly lower than that in control group.The differences were statistically significant(P<0.05).According to the Pearson correlation analysis,the endometrial thickness of patients with PCOS was positively correlated with the AMH,TC,TG,LDL-C and follicle size(P<0.05),and negatively correlated with the HDL-C(P<0.05).Conclusion The endometrial thickness in PCOS patients is closely related to the AMH,blood lipid level and ovarian ultrasound indexes.It suggests that clinicians should closely monitor AMH,blood lipid level and ovarian ultrasound indexes while conducting the treatment to improve the treatment effect.
作者
卫肖
张宸铭
李路凯
吴朵朵
韩春艳
WEI Xiao;ZHANG Chenming;LI Lukai;WU Duoduo;HAN Chunyan(Department of Reproductive Medicine,Henan Province Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450002,China;The Second Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China)
出处
《现代医药卫生》
2022年第3期364-367,共4页
Journal of Modern Medicine & Health
基金
国家自然科学基金项目(81603632)。
作者简介
卫肖(1990-),硕士研究生,主管检验师,主要从事临床检验诊断学及生殖检验诊断研究;通信作者:张宸铭,E-mail:zcmhnzy@163.com。
