摘要
创面愈合作为重要的公共卫生问题之一,一直是世界性难题。由于独特的生物创面环境,创面愈合是一个非常复杂的过程,目前治疗周期长、疗效欠佳,患者经济负担重。越来越多的研究表明,非编码RNA(ncRNA)在创面愈合过程中扮演着重要角色。竞争性内源性RNA(ceRNA)假说是近些年新提出的一种RNA相互调控假说,该假说提出了不同RNA之间的一种“交流方式”。ceRNA调控网络(ceRNET)将蛋白质编码mRNA的功能与ncRNA(如微小RNA、长链非编码RNA、假基因和环状RNA)的功能联系起来。最新的研究表明,ceRNA在创面愈合过程中发挥重要作用,这可能为创面愈合提供新的有效治疗靶标。本文从ceRNET着手,系统综述各种ceRNA在创面愈合中的作用研究进展及未来研究的挑战,旨在深入探究ceRNA在创面愈合过程中的分子机制及临床意义。
Wound healing,as one of the important public health issues,has been a worldwide problem.Due to the unique biological wound environment,wound healing is a very complex process with current treatments requiring long cycles,being poorly effective,and bringing high economic burden to patients.An increasing number of studies have shown that non-coding RNAs(ncRNAs)play important roles in wound healing process.The competing endogenous RNAs(ceRNAs)hypothesis in recent years is a new proposal on the inter-regulation of RNAs,which suggests a"mode of communication"between different RNAs.ceRNA regulatory network(ceRNET)combines the functions of protein-coding mRNA with ncRNA(e.g.,microRNA,long non-coding RNA,pseudogenes,and circular RNA).Recent studies have shown that ceRNAs play important roles in wound healing,which may provide new effective therapeutic targets for wound healing.This paper starting with ceRNET systematically reviewed the research progress on the effects of various ceRNAs in wound healing and the future research challenges,with the aim to deeply explore the molecular mechanisms and clinical significance of ceRNAs in the process of wound healing.
作者
廖银友
张丕红
Liao Yinyou;Zhang Pihong(Department of Burns and Plastic Surgery,Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《中华烧伤与创面修复杂志》
CAS
CSCD
北大核心
2022年第1期84-89,共6页
Chinese Journal of Burns And Wounds
基金
国家自然科学基金面上项目(81772084)。
关键词
伤口愈合
反应元件
竞争性内源性核糖核酸调控网络
竞争性内源性核糖核酸
Wound healing
Response elements
Competing endogenous ribonucleic acid regulatory network
Competing endogenous ribonucleic acid
作者简介
通信作者:张丕红,Email:zphong@aliyun.com.
