摘要
目的探讨来曲唑诱导排卵内膜准备方案对高龄不孕患者冻融胚胎移植(FET)周期妊娠结局的影响。方法回顾性分析2015年1月至2019年12月在秦皇岛市妇幼保健院生殖医学科首次行FET的1058例高龄不孕患者的临床资料,按照子宫内膜准备方案分为来曲唑诱导排卵组(LC组)和自然周期组(NC组),LC组650例,NC组408例。比较两组的一般临床资料、临床妊娠率、着床率、早期流产率、异位妊娠率及活产率。结果两组患者年龄、不孕年限、体重指数(BMI)、基础性激素、抗苗勒管激素(AMH)、移植日内膜厚度、移植胚胎数、移植优胚率、异位妊娠率、早期流产率比较差异均无统计学意义(P>0.05)。LC组的植入窗期雌二醇及孕酮水平、着床率、临床妊娠率、活产率均明显高于NC组(P<0.05)。结论来曲唑诱导排卵内膜准备方案可能通过改善高龄不孕患者的黄体功能提高临床妊娠率和活产率。
Objective To investigate the effect of letrozole induced ovulation endometrial preparation scheme on pregnancy outcome of frozen thawed embryo transfer(FET)cycles in the advanced age infertile patients.Methods The clinical data of 1058 advanced age infertile patients undergoing frozen thawed embryo transfer for the first time in reproductive medicine department of Qinhuangdao Municipal Maternal and Child Health Care Hospital from January 2015 to December 2019 were retrospectively analyzed.According to the endometrial preparation scheme,they were divided into the letrozole induced ovulation group(LC group)and natural cycle group(NC group).There were 650 cases in The LC group and 408 cases in the NC group.The general clinical data,clinical pregnancy rate,implantation rate,abortion rate,ectopic pregnancy rate and live birth rate were compared between the two groups.Results There were no statistically significant differences in age,infertility years,body mass index(BMI),basic sex hormone,anti Mullerian hormone(AMH),endometrial thickness on the day of transplantation,number of transferred embryos,excellent embryo rate,ectopic pregnancy rate and abortion rate between the two groups(P>0.05).The levels of estradiol and progesterone in implantation window period,implantation rate,clinical pregnancy rate and live birth rate in the LC group were significantly higher than those in the NC group(P<0.05).Conclusion The letrozole induced ovulation endometrial preparation scheme improves the clinical pregnancy rate and live birth rate in the advanced age infertile patients possibly by improving the luteal function.
作者
刘聪
李伟伟
李颖敏
董丽霞
张楠
闫娅妮
殷秀荣
LIU Cong;LI Weiwei;LI Yingmin;DONG Lixia;ZHANG Nan;YAN Yani;YIN Xiurong(Department of Reproductive Medicine,Qinhuangdao Municipal Maternal and Child Health Care Hospital,Qinhuangdao,Hebei 066000,China)
出处
《重庆医学》
CAS
2022年第2期219-222,227,共5页
Chongqing medicine
基金
河北省医学科学研究课题计划项目(20191390)
秦皇岛市科学技术研究与发展计划项目(202004A036)。
关键词
高龄
不孕
诱导排卵
冻融胚胎移植
子宫内膜容受性
adcanced age
infertility
ovulation induction
frozen thawed embryo transfer
endometrial receptivity
作者简介
刘聪(1984-),副主任医师,硕士,主要从事生殖医学研究;通信作者:殷秀荣,E-mail:liconglc@163.com。
