摘要
非动脉炎性前部缺血性视神经病变(NAION)作为一组常见的严重危害视功能的视神经疾病,是由于睫状后短动脉灌注不足,使视神经发生急性缺血、结构以及功能紊乱,最终导致视力下降、甚至视力丧失。该病的病因和发病机制复杂,目前认为是局部解剖因素、全身血管危险因素等多因素共同参与,导致治疗上没有明确、统一、公认的治疗方案,早期发现、诊断和治疗对NAION的预后影响极大。目前治疗主要包括:对因治疗、药物治疗、中医治疗、联合用药、视神经鞘减压术、辅助治疗及外泌体治疗。随着近年各类抗NAION药物的不断发展和运用,提出了多种治疗方法,尤其以外泌体为研究热点,被广泛关注。为了更好地治疗NAION、提高治愈率、指导临床工作,本文主要对NAION的近年来的治疗进展做出以下综述。
Nonarterial anterior ischemic optic neuropathy(NAION)is a group of common optic nerve diseases that seriously endanger visual function.It is resulted from insufficient perfusion of the posterior ciliary artery,which causes acute ischemia,structural and functional disorders of the optic nerve,and ultimately leads to hypopsia and even vision loss.The etiology and pathogenesis of this disease is complex.It is nowadays considered that multiple factors including local anatomy,risk of systemic vascular cause this disease together,which result in no clear,unified and recognized treatment.Early detection,diagnosis and treatment are of great significance in the prognosis of NAION.Possible therapeutic methods include etiological treatment,drug therapy,traditional Chinese medicine(TCM)treatment,combined medication,optic nerve sheath decompression,adjuvant treatments and exosomes.With the continuous development and application of various anti-NAION drugs in recent years,a variety of therapeutic methods have been proposed,especially with the exosomes as the research focus.In order to better treat NAION with improvement of the cure rate and guidance for clinical work,this paper mainly reviews the progress in the treatment of NAION in recent years.
作者
杨春芳
梁高华
Chun-Fang Yang;Gao-Hua Liang(Youjiang Medical University for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Department of Ophthalmology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China)
出处
《国际眼科杂志》
CAS
北大核心
2022年第2期255-259,共5页
International Eye Science
基金
广西自然科学基金项目(No.2020GXNSFAA259054)
右江民族医学院附属医院2019年度第一批高层次人才科研项目(No.R20196340,Y20196304)。
关键词
非动脉炎性前部缺血性视神经病变
对因治疗
中医治疗
联合用药
视神经鞘减压术
辅助治疗
外泌体治疗
nonarteritic anterior ischemic optic neuropathy
etiological treatment
traditional Chinese medicine treatment
combined medication
optic nerve sheath decompression
adjuvant treatments
treatment of exosomes
作者简介
杨春芳,在读硕士研究生,研究方向:视神经疾病、干细胞与外泌体在眼科疾病的临床与基础研究;通讯作者:梁高华,毕业于暨南大学,博士,副主任医师,眼科副主任,硕士研究生导师,研究方向:视神经疾病、干细胞与外泌体在眼科疾病的基础与临床研究.417489627@qq.com。
