摘要
目的分析米非司酮联合醋酸甲羟孕酮治疗功能性子宫出血(FUB)的效果及对血清血管内皮生长因子A(VEGFA)、血管内皮生长因子受体-1(sFlt-1)的影响。方法选取2019年4月-2020年4月我院妇科就诊的78例FUB患者作为研究对象,按照随机数字表法分为对照组与观察组,各39例。对照组采用醋酸甲羟孕酮治疗,观察组在对照组基础上联合米非司酮治疗,比较两组临床疗效、止血时间、性激素水平[雌二醇(E_(2))、黄体生成素(LH)、孕酮(P)]、子宫内膜厚度、VEGFA、sFlt-1水平、复发率。结果观察组治疗总有效率为84.62%,高于对照组的61.54%,差异有统计学意义(P<0.05)。观察组控制出血时间及完全止血时间均短于对照组,差异有统计学意义(P<0.05)。观察组E_(2)、LH、P均低于对照组,差异有统计学意义(P<0.05);观察组子宫内膜厚度小于对照组,差异有统计学意义(P<0.05);观察组VEGFA水平低于对照组,sFlt-1水平高于对照组,差异有统计学意义(P<0.05)。治疗后1年,观察组复发率为5.13%,低于对照组的23.08%,差异有统计学意义(P<0.05)。结论米非司酮联合醋酸甲羟孕酮治疗FUB疗效肯定,可缩短患者的止血时间,减小其子宫内膜厚度,同时调节机体性激素水平及血管内皮生长因子的表达,降低复发风险。
Objective To analyze the clinical effect of mifepristone combined with medroxyprogesterone acetate in the treatment of functional uterine bleeding(FUB),and its effect on serum vascular endothelial growth factor A(VEGFA)and vascular endothelial growth factor receptor-1(sFlt-1).Methods A total of 78 patients with FUB admitted to our hospital from April 2019 to April 2020 were selected and divided into control group and observation group according to random number table method,with 39 cases in each group.The control group was treated with medroxyprogesterone acetate,and the observation group was treated with mifepristone on the basis of the control group.The clinical efficacy,hemostasis time,sex hormone levels[estradiol(E_(2)),luteinizing hormone(LH),progesterone(P)],endometrial thickness,VEGFA,sFlt-1 levels,and recurrence rate were compared between the two groups.Results The total effective rate of the observation group was 84.62%,which was higher than 61.54%of the control group,and the difference was statistically significant(P<0.05).The control bleeding time and complete hemostasis time in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The E_(2),LH and P in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The endometrial thickness of the observation group was less than that of the control group,and the difference was statistically significant(P<0.05).The level of VEGFA in the observation group was lower than that in the control group,and the level of sFlt-1 was higher than that in the control group,the difference was statistically significant(P<0.05).One year after treatment,the recurrence rate of the observation group was 5.13%,which was lower than 23.08%of the control group,and the difference was statistically significant(P<0.05).Conclusion Mifepristone combined with medroxyprogesterone acetate in the treatment of FUB is effective,which can shorten the hemostasis time of patients,reduce the endometrial thickness,regulate the expression of sexual hormones and vascular endothelial growth factor in the body,and reduce the risk of recurrence.
作者
陈晓明
CHEN Xiao-ming(Outpatient Pharmacy Bureau of Lingyuan Central Hospital,Lingyuan 122500,Liaoning,China)
出处
《医学信息》
2022年第1期122-125,共4页
Journal of Medical Information
关键词
功能性子宫出血
米非司酮
醋酸甲羟孕酮
血管内皮生长因子
性激素
Functional uterine bleeding
Mifepristone
Medroxyprogesterone acetate
Vascular endothelial growth factor
Sex hormones
作者简介
陈晓明(1973.5-),女,辽宁凌源人,本科,主管药师,主要从事临床药物的研究。
