摘要
目的分析他汀类药物在慢性心力衰竭治疗中应用的效果。方法简单随机选取该院2019年1月—2021年5月收治的慢性心力衰竭患者共60例,随机分组,对照组患者给予常规药物治疗,观察组在对照组基础上给予瑞舒伐他汀治疗。比较两组治疗前后患者总胆固醇、低密度脂蛋白胆固醇、三酰甘油、高密度脂蛋白胆固醇、脑钠肽、超敏C反应蛋白水平及左心室射血分数、慢性心力衰竭疗效、不良反应。结果治疗前,两组患者总胆固醇、低密度脂蛋白胆固醇、三酰甘油、高密度脂蛋白胆固醇、脑钠肽、超敏C反应蛋白水平及左心室射血分数比较,差异无统计学意义(P>0.05),治疗后,两组低密度脂蛋白胆固醇、总胆固醇、三酰甘油、脑钠肽、超敏C反应蛋白水平显著降低,左心室射血分数、高密度脂蛋白胆固醇升高,观察组的各项指标改善程度大于对照组,差异有统计学意义(P<0.05)。观察组临床治疗总有效率(96.67%)高于对照组(70.00%),差异有统计学意义(χ^(2)=5.880,P<0.05)。两组不良反应差异无统计学意义(χ^(2)=0.000,P>0.05)。结论常规药物与他汀类药联合治疗慢性心力衰竭的效果确切,可更好地调节总胆固醇、低密度脂蛋白胆固醇、三酰甘油、高密度脂蛋白胆固醇水平和抗炎,降低脑钠肽水平,纠正心力衰竭,安全性高,值得推广。
Objective To analyze the effect of statins in the treatment of chronic heart failure.Methods A total of 60 patients with chronic heart failure admitted to the hospital from January 2019 to May 2021 were simple randomly selected and randomly divided into groups.Patients in the control group were treated with conventional drugs,and the observation group was treated with rosuvastatin on the basis of the control group.The total cholesterol,low-density lipoprotein cholesterol,triglycerides,high-density lipoprotein cholesterol,brain natriuretic peptide,high-sensitivity C-reactive protein levels,and left ventricular ejection fraction,chronic heart failure efficacy,adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no statistically significant difference in total cholesterol,low-density lipoprotein cholesterol,triglycerides,high-density lipoprotein cholesterol,brain natriuretic peptide,high-sensitivity C-reactive protein levels,and left ventricular ejection fraction between the two groups of patients(P>0.05).After treatment in the two groups,the levels of low-density lipoprotein cholesterol,total cholesterol,triacylglycerol,brain natriuretic peptide,and high-sensitivity C-reactive protein decreased significantly,and the left ventricular ejection fraction and high-density lipoprotein cholesterol increased.The degree of improvement of various indicators in the observation group was greater than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of clinical treatment in the observation group(96.67%)was higher than that in the control group(70.00%),and the difference was statistically significant(χ^(2)=5.880,P<0.05).There was no statistically significant difference in adverse reactions between the two groups(χ^(2)=0.000,P>0.05).Conclusion The combination of conventional drugs and statins has a definite effect in the treatment of chronic heart failure.It can better regulate total cholesterol,low-density lipoprotein cholesterol,triglycerides,high-density lipoprotein cholesterol levels and anti-inflammatory,reduce brain natriuretic peptide levels,and correct heart failure,with high safety,which is worthy of promotion.
作者
沈贯群
SHEN Guanqun(The Second Department of Cardiology,Pizhou People's Hospital,Pizhou,Jiangsu Province,221300 China)
出处
《中外医疗》
2021年第33期96-99,共4页
China & Foreign Medical Treatment
作者简介
沈贯群(1979-),男,本科,副主任医师,研究方向为心血管内科冠心病介入治疗。
