摘要
目的研究阿托伐他汀联合曲美他嗪治疗冠心病的临床效果。方法116例冠心病患者,根据治疗方式不同分为对照组和观察组,每组58例。对照组患者采用曲美他嗪治疗,观察组患者采用阿托伐他汀联合曲美他嗪治疗。比较两组患者治疗前后心功能指标[左心室射血分数(LVEF)、左心室收缩末期内径(LVESd)、左心室舒张末期内径(LVEDd)]、治疗效果及治疗后心绞痛发作次数、心绞痛持续时间。结果治疗后,观察组患者LVEF(48.86±1.21)%高于对照组的(42.84±1.46)%,LVESd(50.14±1.18)mm、LVEDd(34.83±1.12)mm短于对照组的(57.04±1.57)、(38.62±1.05)mm,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率98.28%(57/58)高于对照组的81.03%(47/58),差异具有统计学意义(P<0.05)。治疗后,观察组患者心绞痛发作次数(2.16±0.68)次/周少于对照组的(3.79±0.76)次/周,心绞痛持续时间(3.16±0.98)min/次短于对照组的(4.80±0.23)min/次,差异具有统计学意义(P<0.05)。结论冠心病治疗中应用阿托伐他汀联合曲美他嗪能够改善患者各项心功能指标,并降低其心绞痛发作次数,缩短心绞痛持续时间,提升治疗效果,促进疾病康复,可临床推广应用。
Objective To study the clinical effect of atorvastatin combined with trimetazidine in the treatment of coronary heart disease.Methods A total of 116 patients with coronary heart disease were divided into control group and observation group according to different treatment methods,with 58 cases in each group.Patients in the control group were treated with trimetazidine,and patients in the observation group were treated with atorvastatin and trimetazidine.Both groups were compared in terms of cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd)]before and after treatment,therapeutic effect,frequency of angina attacks,and duration of angina pectoris.Results After treatment,the LVEF(48.86±1.21)%of the observation group was higher than(42.84±1.46)%of the control group,and the LVESd(50.14±1.18)mm and LVEDd(34.83±1.12)mm were shorter than(57.04±1.57)and(38.62±1.05)mm of the control group.All the differences were statistically significant(P<0.05).The total effective rate 98.28%(57/58)in the observation group was higher than 81.03%(47/58)in the control group,and the difference was statistically significant(P<0.05).After treatment,the frequency of angina attacks(2.16±0.68)times/week in the observation group was less than(3.79±0.76)times/week in the control group,and the duration of angina pectoris(3.16±0.98)min/time was shorter than(4.80±0.23)min/time in the control group.All the differences were statistically significant(P<0.05).Conclusion The application of atorvastatin and trimetazidine in the treatment of coronary heart disease can improve the cardiac function indexes of patients,reduce the frequency of angina attacks and the duration of angina pectoris,improve the therapeutic effect,promote the rehabilitation of patients,and can be promoted and applied in clinical practice.
作者
韩艳丽
郭佳琪
HAN Yan-li;GUO Jia-qi(Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,Dalian 116011,China)
出处
《中国实用医药》
2021年第36期116-118,共3页
China Practical Medicine
关键词
阿托伐他汀
冠心病
曲美他嗪
心绞痛
效果
Atorvastatin
Coronary heart disease
Trimetazidine
Angina pectoris
Effect
