摘要
近年来卵巢早衰(premature ovarian failure, POF)的发病率呈上升趋势,且其病因复杂,治疗棘手,因此受到国内外学者的广泛关注。为进一步研究POF的发生发展机制,探讨更好的治疗方案,构建可靠的POF动物模型至关重要。本文将回顾分析近五年国内外专家学者在构建POF小鼠模型的方法,进行综述。比较各种建模方法的优势、不足及与临床的相关性,旨在为POF的临床诊治及基础研究提供理论依据。
In recent years, the incidence of premature ovarian failure(POF) has been increasing. Because of its complex etiology and difficult treatment, POF has attracted wide attention from scholars at home and overseas. To study the occurrence and development of POF, and to find better treatment options, it is essential to construct a reliable animal model of POF. This review will discuss and analyze the method used to construct POF mouse models by domestic and foreign investigators in the past five years. Furthermore, we will compare the advantages, disadvantages and clinical relevance of various modeling method, which aim to provide new insights into the basic scientific understanding and clinical diagnosis and treatment of POF.
作者
潘正美
刘洋
PAN Zhengmei;LIU Yang(Department of Reproductive Medicine,the Second Affiliated Hospital,Kunming Medical University,Kunming 650101,China)
出处
《中国比较医学杂志》
CAS
北大核心
2021年第12期97-102,共6页
Chinese Journal of Comparative Medicine
基金
国家自然基金地区项目(81860515)
云南省“万人计划”青年拔尖人才培养项目云人社发[2018]73号)
云南省“万人计划”名医专项人才项目([2019]35号)
云南省基础研究项目昆医联合专项面上项目(2018FE001(-005))
云南省卫生健康委员会医学学科带头人培养项目(D-2019004)。
关键词
卵巢早衰
小鼠
动物模型
premature ovarian failure
mice
animal models
作者简介
潘正美(1996-),女,在读研究生,研究方向:辅助生殖技术与生殖内分泌和生育力保存。E-mail:panzhm18164621113@163.com;通信作者:刘洋(1979-),女,博士,副主任医师,研究生导师,研究方向:辅助生殖技术与生殖内分泌和生育力保存。E-mail:13518735544@163.com。
