摘要
卵巢早衰(premature ovarian failure,POF)是导致女性不孕症的一个重要原因,但病因和发病机制尚不十分明确。近年来的研究结果表明,POF的病因包括遗传学因素、免疫因素、医源性因素和环境因素等。遗传学因素可能是导致POF的一个重要因素,包括染色体数目与结构的异常、基因突变,都可导致POF。免疫因素导致的POF可能是卵巢内或者体液内存在抗原,使得机体在其他部位产生的抗体同时作用于卵巢产生损害,也可能为自身免疫性疾病导致的异常激素水平影响到女性内分泌。医源性因素主要是有盆腔手术史以及术后放化疗者均有可能导致POF。此外,环境中的一些物质可能破坏卵泡从而导致POF。现将近年来POF的病因学研究进展,尤其是在遗传学因素和免疫学方面的研究进展进行综述,以期为POF的治疗及预防提供依据。
Premature ovarian failure(POF) is an important cause of female infertility. However, the etiology and pathogenesis of POF is not very clear. Recent studies have shown that the etiological factors of POF include genetics, immune, iatrogenic and environmental factors. Genetic factor as an important factor of POF includes numerous abnormalities in chromosome number and structure as well as gene mutation. Immune factor may be due to the presence of antigens in ovaries or body fluids, so that antibodies produced in other parts of the body cause ovarian damage, or the abnormal hormone level caused by autoimmune diseases that may affect female endocrine. Iatrogenic factors of POF mainly include pelvic surgery history and postoperative chemoradiotherapy. In addition, some substances in the environment may damage the follicles and thus cause POF. Recent advances in the etiology of POF, especially in genetic and immunological factors, are reviewed so as to provide a useful reference for the treatment and prevention of POF.
作者
吴结英
胡卫华
WU Jie-ying;HU Wei-hua(Department of Reproductive Medicine, Yijishan Hospital of Wanna Medical College,Wuhu 241001,Anhui Province,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2019年第4期332-336,344,共6页
Journal of International Reproductive Health/Family Planning
基金
芜湖市科技惠民计划(2016hm14)
关键词
卵巢早衰
不育
女(雌)性
基因
突变
染色体畸变
Premature ovarian failure
Infertility,female
Genes
Mutation
Chromosome aberrations
作者简介
通信作者:胡卫华,审校者,E-mail:wnmchwh@163.com.
