摘要
为了发现新的农用高活性化合物,将具有杀螨活性的嗜球果伞素类化合物与具有杀菌活性的吡唑酰胺类化合物的活性亚结构进行拼接,设计并合成了16个新化合物,通过核磁共振氢谱、碳谱及高分辨质谱等手段表征了其结构。生物活性测试结果表明,目标化合物虽然没有预期的杀螨和杀菌活性,但是表现出了良好的杀虫活性,其中8个化合物在500 mg/L下对黏虫Mythimna separata的杀虫活性为100%。
To discovery novel pesticidal compounds,16 new compounds were designed and synthesized by combining several active sub-structures of miticidal strobilurins and fungicidal pyrazole carboxamides.Their structures were determined by 1H NMR,13C NMR and HRMS.The biological activity assay results showed that all target compounds had poor miticidal and fungicidal activities,however,some target compounds had good insecticidal activities.The mortalities against Mythimna separata of 8 compounds were 100%at 500 mg/L.
作者
楼佳明
郝树林
方佳琪
杜晓华
LOU Jiaming;HAO Shulin;FANG Jiaqi;DU Xiaohua(Catalytic Hydrogenation Research Center,Zhejiang University of Technology,Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology,Zhejiang Green Pesticide Collaborative Innovation Center,Hangzhou 310014,China)
出处
《农药学学报》
CAS
CSCD
北大核心
2021年第6期1108-1116,共9页
Chinese Journal of Pesticide Science
基金
国家重点研发计划(2016YFD0300708).
关键词
嗜球果伞素
吡唑-4-甲酰胺
嘧啶硫醚
黏虫
杀虫活性
strobilurin
pyrazole-4-carboxamide
pyrimidine thioether
Mythimna separata
insecticidal activity
作者简介
楼佳明,男,在读研究生,E-mail:loujiaming0429@163.com;通信作者:杜晓华,男,研究员,研究方向为新农药创制和绿色化学合成技术,E-mail:duxiaohua@zjut.edu.cn。
