摘要
目的回顾性分析儿童激素敏感型肾病综合征合并高磷血症的情况,探讨高磷血症在儿童肾病综合征发病中的临床意义。方法选择山东第一医科大学附属省立医院小儿肾脏风湿免疫科在2017年1月至2018年12月期间收治的61例儿童激素敏感型肾病综合征初治患儿,观察在病情活动期和缓解期血磷水平的变化,并分析其与血清白蛋白、血脂、肾功能、血钙、血磷、尿蛋白等指标之间的相关关系。结果61例激素敏感型肾病综合征患儿在病情活动期的血磷水平为1.79(1.65,1.91)mmol/L,其中血磷升高者33例(54.1%);而在病情完全缓解后血磷水平为1.64(1.46,1.79)mmol/L,血磷升高者15例(24.6%)。相关性分析显示,激素敏感型肾病综合征患儿血磷水平与尿蛋白/肌酐比值、血清脂蛋白a、钙磷乘积呈正相关(r值分别为0.239、0.188、0.623,P均<0.05),与血白蛋白水平、血钙水平呈负相关(r值分别为-0.201、-0.195,P均<0.05)。结论激素敏感型肾病综合征患儿在疾病活动期高磷血症的发生率较高,随病情缓解血磷紊乱情况明显改善,具体机制有待进一步研究。
Objective To analyze the relationship between hyperphosphatemia and steroid-sensitive nephrotic syndrome(SSNS)in children.Methods A retrospective study was carried out in 61 children with SSNS at Department of Paediatric Nephrology and Rheumatism and Immunology,Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2017 to December 2018.The changes of serum phosphorus levels during the active and remission stages were observed,and the correlation between serum phosphorus level and serum albumin,blood lipid,renal function,blood calcium,blood phosphorus,urine protein and other indicators were analyzed.Results Serum phosphorus level of 61 children with SSNS was 1.79(1.65-1.91)mmol/L in the active phase of the disease,of which 33 patients(54.1%)had hyperphosphatemia,while serum phosphorus level was 1.64(1.46-1.79)mmol/L after the complete remission,and 15(24.6%)patients had hyperphosphatemia.Serum phosphorus level was positively correlated with ratio of urine protein/creatinine,serum lipoprotein A and calcium-phosphorus product(r=0.239,P<0.05;r=0.188,P<0.05;r=0.623,P<0.05),and negatively correlated with levels of serum albumin and serum calcium(r=-0.201,P<0.05;r=-0.195,P<0.05).Conclusion The morbidity of hyperphosphatemia in children with SSNS is quite high during the active stage of the disease.The disorder of blood phosphorus significantly improve with remission of the disease.
作者
李倩
余丽春
王京
栾春丽
陈元
孙书珍
Li Qian;Yu Lichun;Wang Jing;Luan Chunli;Chen Yuan;Sun Shuzhen(Department of Paediatric Nephrology and Rheumatism and Immunology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Department of Paediatric Nephrology and Rheumatism and Immunology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China)
出处
《中国小儿急救医学》
CAS
2021年第10期864-867,共4页
Chinese Pediatric Emergency Medicine
基金
山东省自然科学基金(ZR2015HM009)
山东省重点研发项目(2017GSF218005)。
关键词
肾病综合征
高磷血症
儿童
Nephrotic syndrome
Hyperphosphatemia
Children
作者简介
通信作者:孙书珍,Email:ssztml@163.com。
