摘要
目的探讨癫痫持续状态患儿血清S100B蛋白、神经元特异烯醇化酶(NSE)、神经肽Y、脑源性神经营养因子(BD-NF)表达及临床意义。方法选取2016年1月至2020年10月河南省儿童医院内科监护室收治的36例癫痫持续状态患儿为癫痫组,男19例,女17例,年龄(5.76±2.37)岁,年龄范围为3~12岁。并选取河南省儿童医院同时期体检的36名健康小儿为健康组,男18名,女18名,年龄(5.56±2.41)岁,年龄范围为3~13岁。比较两组纳入者血清S100B蛋白、NSE、神经肽Y、BD-NF水平,比较癫痫组患儿治疗前后各项水平并进行相关性分析,对患儿癫痫持续状态进行预测价值。结果癫痫组患儿血清S100B蛋白[(0.89±0.17)μg/L]、NSE[(29.33±5.42)μg/ml]、神经肽Y[(287.59±29.41)ng/L]、BD-NF[(1.38±0.22)μg/L]水平均显著高于健康组[(0.15±0.02)μg/L、(5.73±5.73)μg/ml、(169.43±28.24)ng/L、(0.68±0.13)μg/L],差异有统计学意义(P<0.001)。治疗后患儿血清S100B蛋白[(0.43±0.11)μg/L]、NSE[(12.65±2.71)μg/ml]、神经肽Y[(226.17±26.42)ng/L]、BD-NF[(1.09±0.21)μg/L]水平显著低于治疗前,差异有统计学意义(P<0.001)。患儿血清S100B蛋白水平与NSE水平呈正相关(r=0.646,P<0.001);与神经肽Y水平呈正相关(r=0.486,P=0.003);与BD-NF水平呈正相关(r=0.508,P=0.002)。S100B蛋白的曲线下面积(AUC)值为0.763,NSE的AUC值为0.788,神经肽Y的AUC值为0.719,BD-NF的AUC值为0.724,差异有统计学意义(P<0.05)。结论癫痫持续状态患儿血清S100B蛋白、NSE、神经肽Y、BD-NF呈高表达,S100B蛋白、NSE、神经肽Y、BD-NF水平越高,癫痫发生持续状态的风险越大,四项指标均有助于患儿癫痫持续状态的诊断。
Objective To investigate the expression and clinical significance of serum S100B protein,neuron specific enolase(NSE),neuropeptide Y and brain-derived neurotrophic factor(BD-NF)in children with status epilepticus disease.Methods A total of 36 children with epilepsy,including 19 males and 17 females,were admitted to the department of Internal Intensive Care Unit in Henan Children′s Hospital from January 2016 to October 2020 as the epilepsy group,aged(5.76±2.37)years old,ranging from 3 to 12 years old.At the same time,36 healthy children from Henan Children′s Hospital were selected as the healthy group,18 males and 18 females,aged(5.56±2.41)years old,ranging from 3 to 13 years old.The serum S100B protein,NSE,neuropeptide Y,and BD-NF levels of the two groups were compared,and the levels of the children in the epilepsy group were compared before and after treatment and correlation analysis was performed to predict the value of status epilepticus.Results The epilepsy group serum S100B protein[(0.89±0.17)μg/L],NSE[(29.33±5.42)μg/ml],neuropeptide Y[(287.59±29.41)ng/L],BD-NF[(1.38±0.22)μg/L]level is significantly higher than the healthy group[(0.15±0.02)μg/L,(5.73±5.73)μg/ml,(169.43±28.24)ng/L,(0.68±0.13)μg/L],The difference was statistically significant(P<0.001).Serum S100B protein[(0.43±0.11)μg/L],NSE[(12.65±2.71)μg/ml],neuropeptide Y[(226.17±26.42)ng/L],BD-NF[(1.09±0.21)μg/L]level was significantly lower than before treatment,the difference was statistically significant(P<0.001).Serum S100B protein level was positively correlated with NSE level(r=0.646,P<0.001);it was positively correlated with neuropeptide Y level(r=0.486,P=0.003);it was positively correlated with BD-NF level(r=0.508,P=0.002).The area under curve(AUC)value of S100B protein was 0.763,the AUC value of NSE was 0.788,the AUC value of neuropeptide Y was 0.719,and the AUC value of BD-NF was 0.724,the difference was statistically significant(P<0.05).Conclusion The serum levels of S100B protein,NSE,neuropeptide Y and BD-NF were highly expressed in children with status epilepticus.The higher the levels of S100B protein,NSE,neuropeptide Y and BD-NF,the higher the risk of status epilepticus,all four indicators contribute to the diagnosis of status epilepticus.
作者
张群群
刘灵芝
吕艳琦
苏军
金志鹏
Zhang Qunqun;Liu Lingzhi;Lyu Yanqi;Su Jun;Jin Zhipeng(Department of Internal Intensive Care Unit,Children′s Hospital Affiliated to Zhengzhou University,Henan Children′s Hospital,Zhengzhou Children′s Hospital,Zhengzhou 450000,China)
出处
《中国临床实用医学》
2021年第5期3-7,共5页
China Clinical Practical Medicine
基金
河南省科技攻关计划联合共建项目(LHGJ20190957)。
作者简介
通信作者:金志鹏,Email:13601672919@163.com。
