摘要
水鬼蕉Hymenocallis littoralis为石蒜科多年生草本植物,具有抗肿瘤、抗病毒及抗炎等多种药理活性。生物碱作为其代表性化学成分一直以来受到诸多关注,而其他类成分报道较少。水鬼蕉中非生物碱成分的化学组成如何值得探究。鉴于此,该文运用多种色谱分离方法并利用波谱学技术,从水鬼蕉干燥全草的95%乙醇提取物中共分离得到13个非生物碱单体化合物,分别为5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromen-4-one(1)、undulatoside A(2)、(2S)-7,4′-dihydroxyflavane(3)、柚皮素(4)、4′,7-hydroxy-8-methylflavanone(5)、8-methylnaringenin(6)、8-去甲杜鹃素(7)、6-methyl-aromadendrin(8)、4′,5,7-三羟基-8-甲基黄烷酮(9)、syzalterin(10)、6-methylapigenin(11)、异甘草酸(12)和undatuside C(13)。其中,化合物1为1个新色原酮衍生物,化合物2和4~13均为首次从该植物中分离得到。
Perennial herb Hymenocallis littoralis(Amaryllidaceae)boasts anti-tumor,anti-virus,and anti-inflammatory activities.As the representative constituents,alkaloids have attracted much attention,whereas the non-alkaloid constituents have been rarely reported.Therefore,this study investigated the non-alkaloid constituents of H.littoralis and their contribution to the various pharmacological activities of the herb.Thirteen non-alkaloid compounds were isolated from the 95%ethanol extract of dried whole plant of H.littoralis after a series of chromatographic separation steps and spectral analysis,and they were identified as 5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromoen-4-one(1),undulatoside A(2),(2S)-7,4′-dihydroxyflavane(3),naringenin(4),4′,7-hydroxy-8-methylflavanone(5),8-methylnaringenin(6),8-demethylfarrerol(7),6-methyl-aromadendrin(8),4′,5,7-trihydroxy-8-methylflavanone(9),syzalterin(10),6-methylapigenin(11),isoliquiritigenin(12),and undatuside C(13)based on the spectroscopic data analysis.Among them,compound 1 was a new chromone derivative,and compounds 2 and 4-13 were isolated form this plant for the first time.
作者
段志文
张洁
陈晓娟
庞旭
马百平
DUAN Zhi-wen;ZHANG Jie;CHEN Xiao-juan;PANG Xu;MA Bai-ping(Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Science,Beijing 100850,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第20期5304-5309,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81803385)
中国博士后科学基金项目(2019M653957)。
关键词
石蒜科
水鬼蕉
非生物碱类成分
分离
结构鉴定
Amarylliaceae
Hymenocallis littoralis
non-alkaloid constituents
isolation
structural identification
作者简介
段志文,硕士研究生,E-mail:18974784310@163.com;通信作者:庞旭,助理研究员,E-mail:pangxu320@163.com;通信作者:马百平,研究员,E-mail:mabaiping@sina.com。
