摘要
孟德尔随机化是工具变量分析的一种类型,由于其自身特殊的优势及基因组学的迅速发展,近年来受到医学研究领域的青睐。了解孟德尔随机化的原理、方法及局限性对于正确应用孟德尔随机化方法及解读结果至关重要。本文旨在介绍孟德尔随机化的基本概念、原理、方法和局限性,以期为研究者进行孟德尔随机化研究提供指导。
Mendelian randomization is a special type of instrumental variable analysis. Its application in the medical field increases in popularity because of its obvious advantages and the rapid development of genomics. This article aimed to introduce the basic concepts, principles, common methods, and limitations of Mendelian randomization. It is expected to provide guidance for researchers to conduct Mendelian randomization studies.
作者
于天琦
徐文涛
苏雅娜
李静
YU Tianqi;XU Wentao;SU Yana;LI Jing(Research Center of Evidence-Based Medicine and Clinical Epidemiology,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2021年第10期1227-1234,共8页
Chinese Journal of Evidence-based Medicine
作者简介
通信作者:李静,Email:lijing68@Hotmail.com。
