摘要
目的:探究2型糖尿病(T2DM)患者血清分泌型卷曲蛋白5(sFRP5)水平与糖脂代谢、骨代谢及骨密度的关系。方法:选取T2DM患者150例(T2DM组),另选取同期OGTT试验证实为正常糖耐量(NGT)者108例(NGT组)。检测两组血清sFRP5水平,糖脂代谢指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹血清胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高度脂蛋白胆固醇(HDL-C)],骨代谢指标[N端骨钙素(N-MID)、Ⅰ型前胶原氨基端前肽(PINP)、Ⅰ型胶原羟基端肽β降解产物(β-CTX)]。双能X吸收法检测腰椎骨密度(BMD)。结果:T2DM组HbA1c、FPG、2hPG、FINS、HOMA-IR、TG、LDL-C、BMD均高于NGT组,HDL-C、sFRP5、N-MID、PINP、β-CTX水平均低于NGT组(P<0.05)。在剔除年龄影响后,T2DM患者血清sFRP5与HbA1c、FPG、2hPG、FINS、HOMA-IR、TG及BMD负相关(r=-0.439、-0.436、-0.448、-0.288、-0.456、-0.160、-0.423,P<0.05),与TC、HDL-C、LDL-C、N-MID、PINP及β-CTX正相关(r=0.170、0.366、0.135、0.625、0.583、0.601,P<0.05)。线性回归分析结果显示,调整年龄后,T2DM患者血清sFRP5可负向影响HbA1c、FPG、2hPG、FINS、HOMA-IR、TG、BMD(β分别为-0.115、-0.170、-0.402、-0.224、-0.139、-0.029、-0.039,P<0.05),正向影响TC、HDL-C、LDL-C、N-MID、PINP、β-CTX(β分别为0.038、0.041、0.019、0.408、1.065、0.021,P<0.05)。结论:血清sFRP5水平与T2DM患者糖脂代谢、骨代谢关系密切,可能参与T2DM患者骨质疏松的发病过程。
Aim:To explore the correlation between serum secretory frizzled protein 5(SFRP5)and glucose and lipid metabolism,bone metabolism and bone mineral density in type 2 diabetes mellitus(T2DM)patients.Methods:A total of 150 T2DM patients were selected as the T2DM group,and 108 patients with OGTT test as normal glucose tolerance(NGT)were the NGT group.Serum SFRP5 level,glucose and lipid metabolism indexes[fasting blood glucose(FPG),hemoglobin A1c(HbA1c),fasting serum insulin(FINS),insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high lipoprotein cholesterol(HDL-C)],bone metabolism indexes[N-terminal osteocalcin(N-MID),procollagen typeⅠN-terminal propeptide(PINP),C-terminal peptideβdegradation product(β-CTX)of typeⅠcollagen]and bone mineral density(BMD)were analyzed.Results:HbA1c,FPG,2hPG,FINS,HOMA-IR,TG,LDL-C,BMD in T2DM group were higher than those in NGT group,the levels of HDL-C,SFRP5,N-MID,PINP andβ-CTX in T2DM group were lower than those in NGT group(P<0.05).Partial correlation analysis showed,after removing the age effects,serum sFRP5 negatively correlated with HbA1c,FPG,2hPG,FINS,HOMA-IR,TG,and BMD in T2DM group(r=-0.439,-0.436,-0.448,-0.288,-0.456,-0.160,-0.423,P<0.05),and positively correlated with TC,HDL-C,LDL-C,N-MID,PINP andβ-CTX(r=0.170,0.366,0.135,0.625,0.583,0.601,P<0.05).Linear regression analysis revealed that in T2DM group serum sFRP5 could negatively affect HbA1c,FPG,2hPG,FINS,HOMA-IR,TG and BMD(βwas-0.115,-0.170,-0.402,-0.224,-0.139,-0.029,-0.039,P<0.05),and positively affect TC,HDL-C,LDL-C,N-MID,PINP,β-CTX(βwas 0.038,0.041,0.019,0.408,1.065,0.021,P<0.05).Conclusion:Serum SFRP5 level is closely related to glucose and lipid metabolism,bone metabolism in patients with T2DM,and may be involved in the pathogenesis of osteoporosis in patients with T2DM.
作者
李晓蕾
齐晓玲
徐礼五
许敏
LI Xiaolei;QI Xiaoling;XU Liwu;XU Min(Department of Endocrinology,the First Affiliated Hospital,Anhui University of Science and Technology(the First People′s Hospital of Huainan),Huainan,Anhui 232000;Department of Endocrinology,the First Affiliated Hospital,Anhui Medical University,Hefei 230022)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2021年第5期666-670,共5页
Journal of Zhengzhou University(Medical Sciences)
基金
安徽省高校自然科学研究项目(KJ2019A0094)。
关键词
2型糖尿病
分泌型卷曲蛋白5
糖脂代谢
骨代谢
骨密度
type 2 diabetes
secretory frizzled protein 5
glycolipid metabolism
bone metabolism
bone mineral density
作者简介
通信作者:许敏,女,1980年7月生,博士,副主任医师,研究方向:内分泌疾病,E-mail:lixiaolei195210@163.com。
