摘要
目的探讨成纤维细胞生长因子辅助引导骨再生术在前牙种植修复中的应用效果。方法选择2018年2月至2019年11月94例实施前牙种植修复患者,其中男性51例,女性43例;年龄19~57岁,平均年龄41.9岁;牙缺失时间3~11个月,平均缺失时间6.68个月;龋病45例,牙周病29例,外伤12例,其他8例;单牙缺失79例,多牙缺失15例;需要的种植牙数目1~3颗,平均种植牙数目1.20颗;术前骨高度11~16 mm,平均骨高度14.30 mm;前牙列不拥挤25例,Ⅰ度拥挤40例,Ⅱ度拥挤25例,Ⅲ度拥挤4例;覆盖0~4分,平均覆盖1.46分;覆合0~3分,平均覆合1.02分。按随机数字表法,将患者分观察组、对照组。对照组47例,牙种植后行引导骨再生术。观察组47例,于对照组基础上,联合运用成纤维细胞生长因子。对2组术前、术后6个月骨密度、骨厚度、牙槽骨唇舌向宽度,牙龈健康情况,龈沟液炎性因子水平及患者满意度予以比较。结果两组术前骨密度、骨厚度、牙槽骨唇舌向宽度比较,差异无统计学意义(P> 0.05);术后6个月,与同期对照组比较,观察组上述指标分别为(1.81±0.22) g/cm^(2)、(2.92±0.44) mm、(6.52±0.41) mm,明显较大(P <0.05)。两组术前菌斑指数(PLI)、牙龈探诊深度(PD)及牙龈出血指数(SBI)比较,差异无统计学意义(P> 0.05);术后6个月,与同期对照组比较,观察组上述指标水平明显较小(P <0.05)。两组术前龈沟液白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平比较,差异无统计学意义(P> 0.05);术后6个月,与同期对照组比较,观察组上述指标水平分别为(4.79±0.95) pg/mL、(2.46±0.59) ng/L、(4.51±0.89) pg/mL,明显较低(P <0.05)。观察组种植修复满意率为97.87%,与对照组(82.98%)比较,明显较高(P <0.05)。结论成纤维细胞生长因子辅助引导骨再生术在前牙种植修复中的应用,可促进骨生成,减轻牙龈炎症反应,提高患者满意度,值得推广。
Objective To probe effect of fibroblast growth factor assisted guided bone regeneration in implantation restoration of anterior teeth. Methods From February 2018 to November 2019, 94 patients with anterior teeth implantation restoration were enrolled, which included 51 males and 43 females, aged 19-57 years old with mean age of 41.9 years old;tooth loss time was 3-11 months with mean time of 6.68 months;there were 45 cases of dental caries, 29 of periodontal disease, 12 of trauma and 8 of others;Among them 79 cases were single-tooth loss and 15 of multiple-tooth loss. The implantation number of teeth was 1-3 with mean implantation of 1.20. The preoperative bone height was 11-16 mm with mean of 14.30 mm. Based on crowding degree of anterior dentition, there were 25 cases with un-crowding, 40 Ⅰ degree crowding, 25 Ⅱ degree crowding and 4 Ⅲ degree crowding. The overbite was 0-4 scores with mean of 1.46 scores;deep bite 0-3 scores with mean of1.02 scores. According to random number table, all of them were divided into control group(n = 47, performed guided bone regeneration after dental implantation) and observation group(n = 47, combined with fibroblast growth factor on the basis of control group). The bone mineral density, bone thickness, labial lingual width of alveolar bone, gingival health, inflammatory factors in gingival crevicular fluid and patient satisfaction before operation and 6-month post operation between 2 groups were compared. Results Before operation, there were no significant differences in bone mineral density, bone thickness and alveolar lingula width between 2 groups(P > 0.05). Six-month post operation, the above indicators of observation group [(1.81 ±0.22) g/cm^(2),(2.92 ± 0.44) mm, and(6.52 ± 0.41) mm] were significantly larger than those of control group(P < 0.05). Before operation, there were no statistically significant differences in preoperative plaque index(PLI), gingival probing depth(PD) and sulcus bleeding index(SBI) between 2 groups(P > 0.05);6-month post operation, the above indicators of observation group was significantly lower than those of control group(P < 0.05). Before operation, there were no significant differences in levels of interleukin 1β(IL-1β), tumor necrosis factor α(TNF-α) and interleukin 6(IL-6) in gingival crevicular fluid between 2 groups(P >0.05);the above indicators of observation group [(4.79 ± 0.95) pg/mL,(2.46 ± 0.59) ng/L,(4.51 ± 0.89) pg/mL] were significantly lower than those of control group(P < 0.05) at 6-month post operation. The satisfaction rate in observation group(97.87 %) was significantly higher than that in control group(82.98 %)(P < 0.05). Conclusion It is demonstrated that fibroblast growth factor assisted guided bone regeneration in implantation restoration of anterior teeth can promote bone formation, reduce gingival inflammatory reaction and improve patient satisfaction, which is worthy of clinical application.
作者
倪俊鑫
王利宏
赖思煜
刘建林
NI Jun-xin;WANG Li-hong;LAI Si-yu;LIU Jian-lin(Department of Stomatology,Shenzhen Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 518000,Guangdong,China)
出处
《生物医学工程与临床》
CAS
2021年第5期563-568,共6页
Biomedical Engineering and Clinical Medicine
关键词
成纤维细胞生长因子
引导骨再生术
前牙种植修复
牙龈健康状况
炎症反应
fibroblast growth factor
guided bone regeneration
anterior teeth implant repair
gingival health
inflammatory response
作者简介
倪俊鑫(1982-),男,广东陆丰市人,本科,主治医师,主要从事口腔种植研究和口腔临床诊疗T作。电话:0755-89663829。E-mail:mskf666@163.com。
