摘要
脓毒症病理机制复杂,涉及病原体侵入、炎性因子释放、凝血机制紊乱和微循环功能障碍导致组织代谢紊乱及器官功能衰竭。近年来,免疫代谢理念的提出引发了人们对脓毒症营养治疗和免疫干预研究的持续关注。营养代谢分子包括氨基酸、脂肪酸和糖类代谢物,其不仅是营养成分,还是固有免疫和适应性免疫的调节因子;游离脂肪酸受体和AMP依赖的蛋白激酶/哺乳动物雷帕霉素靶蛋白(AMPK/mTOR)信号通路是脂肪酸及糖代谢分子启动免疫调节的主要途径。本文就营养代谢分子在脓毒症营养治疗和免疫调节方面的研究进展进行综述,以期为脓毒症辅助代谢治疗提供新方向。
The pathology of sepsis is extremely complex.Pathogen invasion,inflammatory factors secretion,coagulation disorder and microcirculation disturbance lead to metabolic disorder and organ dysfunction.In recent years,immunometabolism has aroused continuous attention in aspect of nutrition therapy and immune intervention for sepsis.Nutrition metabolites include amino acids,fatty acids,and glucose metabolites,which are not only the nutritional ingredients,but also the regulators of innate immune and adaptive immune.Fatty acids and glucose metabolites are involved in regulation of immune response mainly via free fatty acid receptors and AMP-activated protein kinase/mammalian target of rapamycin(AMPK/mTOR)signaling pathway.Here,we summarized the research progress on the roles of nutrition metabolites in nutrition therapy and immune regulation during sepsis,which could provide a new direction for the development of metabolic therapy for sepsis.
作者
刘田恬
张育才
王春霞
Liu Tiantian;Zhang Yucai;Wang Chunxia(Department of Critical Care Medicine,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai 200062,China;Institute of Pediatric Critical Care,Shanghai Jiao Tong University,Shanghai 200062,China;Institute of Pediatric Infection,Immunity and Intensive Care Medicine,Shanghai Jiao Tong University,Shanghai 200062,China;Clinical Research Unit,Shanghai Children's Hospital,Shanghai 200062,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2021年第8期1017-1020,共4页
Chinese Critical Care Medicine
基金
上海市自然科学基金(19ZR1442500)。
关键词
脓毒症
免疫代谢
氨基酸
脂肪酸
糖代谢分子
Sepsis
Immunometabolism
Amino acid
Fatty acid
Glucose metabolites
作者简介
通信作者:王春霞,Email:wangcx@shchildren.com.cn。
