摘要
目的:探究患者华法林抗凝治疗中影响国际标准化比值(INR)达标的因素。方法:对2019年1月至2021年5月中山市人民医院300例接受华法林抗凝治疗的出院患者进行一般资料、病史、随访情况等问卷调查,以INR是否达标为因变量,分析患者华法林抗凝治疗中INR达标的影响因素。结果:300例患者中,INR值未达标169例、达标131例,达标率为43.67%;经单因素分析,结果显示年龄、文化程度、经济收入、人种基因、患者服药依从性、脑梗死病史、药师是否院外指导为患者华法林抗凝中INR达标影响因素;多元Logistic回归分析结果显示,年龄、文化程度、患者服药依从性、人种基因、药师院外指导为患者华法林抗凝治疗中INR不达标的独立影响因素。结论:患者应用华法林抗凝治疗中,INR达标情况与其年龄、文化程度、人种基因、用药依从性、药师院外干预相关,需加强药师院外针对性健康指导,以保证抗凝治疗质量。
Objective Explore the factors that affect the achievement of the international normalized ratio (INR) in patients with warfarin anticoagulation therapy.Method From January 2019 to May 2021,300 discharged patients from Zhongshan People’s Hospital who received warfarin anticoagulation therapy were surveyed for general information,medical history,follow-up,etc.Questionnaire surveys were conducted,and whether the INR value reached the standard was used as the dependent variable to analyze the patient’s Warfare Influencing factors of INR value in Lin anticoagulation treatment.Result Among the 300 patients,169 cases did not meet the INR value,and 131 cases reached the target,with a compliance rate of 43.67%;single factor analysis showed that age,education level,economic income,ethnic genes,patient medication compliance,history of cerebral infarction,Whether the pharmacist is instructed outside the hospital is the influencing factor of the INR value in the anticoagulation treatment of warfarin;the results of multivariate logistic regression analysis show that age,education level,patient compliance with medication,ethnic genes,and out-of-hospital guidance of the pharmacist indicate that the INR value in the warfarin anticoagulation treatment of the patient is not Independent factors influencing compliance.Conclusion In patients applying warfarin anticoagulation therapy,the INR value compliance is related to age,education level,ethnic genes,medication compliance,and out-of-hospital interventions by pharmacists.It is necessary to strengthen targeted health guidance out-of-hospital by pharmacists to ensure the quality of anticoagulation treatment.
作者
程小荣
廖础欣
刘锐锋
王桂凤
CHENG Xiao-rong;LIAO Chu-xin;LIU Rui-feng;WANG Gui-feng(Zhongshan People's Hospital,Guangdong Zhongshan 528403)
出处
《深圳中西医结合杂志》
2021年第14期17-19,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
中山市社会公益科技研究项目资助课题(2019B1080)(2018B1059)。
关键词
华法林
国际标准化比值
抗凝治疗
Warfarin
International standardized ratio
Anticoagulant therapy
作者简介
程小荣,男,副主任药师,主要从事医院药学工作;通信作者:廖础欣(E-mail:liaochuxinzs@163.com,Tel:13640426238)。
