摘要
卵泡抑素(FST)是一种由垂体、肝、骨等多种组织合成分泌的单链糖蛋白,广泛分布于人体组织中,具有多种生理病理功能。体内外实验证实FST在炎症、骨损伤、肌肉萎缩等方面均有治疗价值。FST在维持口腔颌面部组织内环境稳态中发挥了关键作用,具有治疗口腔炎症、颌骨损伤等疾病的潜在价值,对牙齿、唇、腭、颌骨等软硬组织的发育也非常重要。FST在口腔颌面部上皮和间充质组织中均有表达,通过结合激活素和骨形态发生蛋白拮抗转化生长因子β信号通路,参与调控口腔颌面部的组织发育和相关疾病的发生发展。本文着重阐述FST在口腔颌面部发育及疾病中的作用、机制和应用前景,旨在为其在口腔医学领域的进一步研究和临床应用奠定基础。
Follistatin(FST) is a single-chain glycoprotein synthesized and secreted by pituitary, liver, bone, and other tissues. It has extensive tissue distribution and a variety of physiological and pathological functions proven to have therapeutic value in inflammation, bone injury, and muscle atrophy by in vivo and in vitro experiments. Recent studies have demonstrated that FST plays a key role in maintaining the homeostasis of oral and maxillofacial tissues. FST has potential value in the treatment of oral inflammation, bone injury, and other diseases and is particularly important for the development of soft and hard tissues, such as teeth, lip, palate, and jaw. FST expresses in oral and maxillofacial epithelium and mesenchyme, where it antagonizes the transforming growth factor-β signaling pathway through binding to activin and bone morphogenetic proteins. Therefore, it participates in the regulation of oral and maxillofacial development as well as the occurrence and development of related diseases. This paper focuses on the role, mechanism, and application prospect of FST in oral and maxillofacial development and diseases in order to lay a foundation for its further research and clinical application in the field of stomatology.
作者
刘嘉程
孟昭松
李宏捷
隋磊
Liu Jiacheng;Meng Zhaosong;Li Hongjie;Sui Lei(Dept.of Pathology,School&Hospital of Stomatology,Tianjin Medical Univer‐sity,Tianjin 300070,China;Dept.of Oral and Maxillofacial Surgery,School&Hospital of Stomatology,Tianjin Medi‐cal University,Tianjin 300070,China;Dept.of Prosthodontics,School&Hospital of Stomatology,Tianjin Medical University,Tianjin 300070,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2021年第5期556-562,共7页
International Journal of Stomatology
基金
国家自然科学基金(81700927)。
关键词
卵泡抑素
生长发育
鳞状细胞癌
炎症
骨再生
follistatin
growth and development
squamous cell cancer
inflammation
bone regeneration
作者简介
刘嘉程,学士,Email:928299023@qq.com;通信作者:隋磊,主任医师,博士,Email:suilei@tmu.edu.cn。
