摘要
目的探讨布地奈德联合不同药物雾化吸入治疗儿童支气管哮喘的疗效及对患儿外周血血清淀粉样蛋白A的影响。方法选择2017年1月—2019年5月本院收治的150例急性发作期支气管哮喘患儿作为研究对象,随机数表法分为观察组和对照组两组,每组各75例。对照组给予布地奈德联合特布他林雾化吸入,观察组给予布地奈德联合特布他林、异丙托溴铵雾化吸入,2次/d,1周为1疗程。治疗1疗程后对比2组患儿的临床疗效、肺功能、日间和夜间症状评分、血清CRP、IL-6、TNF-α及SAA水平、不良反应。结果观察组有效率(73/75,97.3%)高于对照组(64/75,85.3%),差异有统计学意义(χ2=8.132,P=0.003);治疗后观察组FEV1和FEV1/FVC高于对照组,差异有统计学意义(t=4.208,4.095,P=0.000,0.000);治疗后观察组日间、夜间症状评分低于对照组,差异均有统计学意义(P<0.001);观察组CRP、IL-6、TNF-α及SAA水平低于对照组,差异具有统计学意义(t=2.008,2.583,2.107,2.304,P=0.045,0.012,0.037,0.026)。结论布地奈德联合特布他林、异丙托溴铵雾化吸入治疗小儿支气管哮喘效果显著,改善临床症状,提高肺功能,降低血清炎性因子水平。
Objective To investigate the effect of joint atomization inhalation with budesonide and different drugs on children with bronchial asthma and the influence on serum amyloid A(SAA)in peripheral blood.Methods 150 children with acute bronchial asthma from January 2017 to May 2019 were enrolled in the study,and they were randomly divided into observation group and control group according to random number table method,with 75 cases in each group.The children in control group were given budesonide combined with terbutaline atomization inhalation,while the children in observation group were given budesonide combined with terbutaline,ipratropium bromide atomization inhalation,twice a day,a treatment course consist of one week.After one course of treatment,the clinical efficacy,lung function,daytime and night symptom scores,serum CRP,IL-6,TNF-αand SAA levels and adverse reactions of the two groups were compared.Results The effective rate of the observation group(73/75,97.3%)was higher than that of the control group(64/75,85.3%)(χ2=8.132,P=0.003).The FEV1 and FEV1/FVC of the observation group were higher than those of the control group after treatment(t=4.208,4.095,P=0.000,0.000).The daytime and night symptom scores of the observation group after treatment were lower than those of the control group(P<0.001).The levels of CRP,IL-6,TNF-αand SAA in the observation group were lower than those in the control group(t=2.008,2.583,2.107,2.304;P=0.045,0.012,0.037,0.026).Conclusions Budesonide combined with terbutaline and ipratropium atomization inhalation in the treatment of children with bronchial asthma has significant effect,it could improve the clinical symptoms and the pulmonary function,reduce the serum SAA and inflammatory level.
作者
刘彩丽
米沛明
廖翠乐
Liu Caili(Department of pediatrics,maternity and child care hospital of Qingyuan,Qingyuan,Guangdong,511500,China)
出处
《齐齐哈尔医学院学报》
2021年第13期1133-1136,共4页
Journal of Qiqihar Medical University
作者简介
通信作者:刘彩丽,Email:liucaili70@163.com。
