摘要
目的研究全程护理措施应用于利妥昔单抗治疗自身免疫性脑炎后的安全性和有效性。方法选择2019年1月至2020年6月广东三九脑科医院神经内一科收治的自身免疫性脑炎患者42例;给予统一编号后采用前瞻性研究按照电脑分配的方式将42例患者分为常规组和试验组,分别在实施利妥昔单抗治疗的同时辅以常规护理干预(n=21)和全程护理干预(n=21),以对比的方式研究两种全程护理干预措施对患者临床用药安全性、生命体征及生活质量及心理状态等方面的干预影响效果。结果常规组护理后不良反应发生率为28.57%(6/21),试验组护理后不良反应发生率为4.76%(1/21),差异有统计学意义(P<0.05)。两组护理前的生命体征[体温、脉搏、血压(舒张压、收缩压)、呼吸、血氧饱和度]比较,差异无统计学意义(P>0.05);组内护理后生命体征均优于护理前,差异有统计学意义(P<0.05);两组间护理前、护理后的各项指标比较,差异无统计学意义(P>0.05)。两组患者护理前均存在显著的焦虑忧郁心理且程度相当,差异无统计学意义(P>0.05);护理后试验组心理状态[焦虑(SAS)、抑郁(SAS)]以及生活质量的改善均优于常规组,差异有统计学意义(P<0.05)。结论对于利妥昔单抗治疗自身免疫性脑炎患者进行全程护理干预,可以改善患者的心理状态及生活质量,提高用药安全性,值得临床进一步推广。
Objective To study the clinical intervention effects such as safety and effectiveness of whole course nursing in rituximab for autoimmune encephalitis.Methods This study was conducted from January 2019 to June 2020,and 42 patients with autoimmune encephalitis randomly admitted to the Department of Neurology I of Guangdong 999 Brain Hospital were selected as the study subjects.These 42 patients were uniformly numbered before the initiation of the retrospective study.In addition,they were divided into the conventional group(n=21)and the experimental group(n=21)according to computer assignment.Both groups were treated with rituximab,and were supplemented with conventional nursing intervention and whole course nursing intervention respectively.The effects of the two nursing interventions on the medication safety in clinic,vital signs,quality of life and psychological status of the patients were studied comparatively.Results The incidence of adverse reactions was 28.57%(6/21)in the conventional group and 4.76%(1/21)in the experimental group,with statistically significant differences(P<0.05).There were no statistically significant differences between the two groups in the vital signs(body temperature,pulse,blood pressure[diastolic pressure and systolic pressure],respiration,and oxygen saturation)before nursing intervention(P>0.05).Meanwhile,the vital signs after nursing intervention in both groups were better than those before nursing intervention,with statistically significant dif ferences(P<0.05).There were no statistically significant differences between the two groups in all indicators before and after nursing intervention(P>0.05).Before nursing intervention,patients in both groups had significant anxiety and depression with similar degrees,and the difference was not statistically significant(P>0.05).After nursing intervention,the improvements in psychological status(anxiety[self-rating anxiety scale,SAS]and depression[self-rating depression scale,SAS])and quality of life in the experimental group were all better than those in the conventional group,with statistically significant d i f f e r e n c e s(P<0.05).Conclusion The whole course nursing intervention for patients with autoimmune encephalitis treated with rituximab can improve psychological status and quality of life of patients,and enhance the safety of medication,which is worthy of further clinical promo tion.
作者
奚玲如
刘志红
张康华
李波
XI Lingru;LIU Zhihong;ZHANG Kanghua;LI Bo(Department of Neurology I,Guangdong 999 Brain Hospital,Guangdong,Guangzhou 510510,China)
出处
《中国医药科学》
2021年第14期107-110,150,共5页
China Medicine And Pharmacy
基金
广东省医学科学技术研究基金项目(B2020107)。
