摘要
目的对灵芝孢子相关研究进行文献计量、可视化分析,探讨并综述其研究热点及发展趋势。方法在中国知网、Pubmed和Web of Science数据库检索灵芝孢子粉相关的文献,并根据文献语言的不同分为中文与英文2个部分,应用CiteSpace对文献中的国家、机构、关键词和主题词、被引情况进行共现分析,绘制对应知识图谱、时间线视图,进而推断灵芝孢子粉的研究热点及趋势。对灵芝孢子主要研究热点、趋势、临床研究及物质基础等方面的研究进行总结。结果共获得相关文献1477篇,包括989篇中文文献、488篇英文文献,发文量均呈增涨趋势,且国家及机构共现分析表明发文的主要是中国与中国机构,研究热点领域为药理药效方面,主要以抗肿瘤、免疫调节、抗癫痫等药效研究为主。近5年新兴的灵芝孢子粉的研究集中在免疫检查点、肠道菌群等前沿领域。结论灵芝孢子粉在抗肿瘤、免疫调节、抗癫痫等方面的药理作用研究广泛,具有良好的应用前景,但物质基础和质量控制研究较为薄弱,有待进一步深化。
OBJECTIVE To analyze the literature metrology and visualization of the research of Ganoderma lucidum spore,to explore and summarize the research hotspots and development trends.METHODS Literatures related to Ganoderma lucidum spore powder were searched in CNKI,Pubmed and Web of Science databases,according to the different languages of the literature,it was divided into Chinese and English.CiteSpace was applied in the co-occurrence of country,institution,keywords,subject words and co-cited analysis,draw the corresponding knowledge map,the timeline view,and concluded the research hotspot and trend of Ganoderma lucidum spore powder.The main research hotspots,trend,clinical research and material basis of Ganoderma lucidum spore powder was summarized.RESULTS A total of 1477 related papers were obtained,including 989 Chinese papers,488 English papers,both showed a trend of rise,and the countries and organizations co-occurrence analysis showed that China and Chinese institutions as the main research unit,the research focus areas were pharmacological efficacy,which was mainly in anti-tumor,immune regulation,anti-epilepsy and other efficacy studies.Nearly five years emerging research focused on immune checkpoints,gut microbes.CONCLUSION Ganoderma lucidum spore powder has been widely studied in anti-tumor,immune regulation,anti-epilepsy,and has a good application prospect,but the research on material basis and quality control is relatively weak,and needs further study.
作者
赵建霞
李振宇
张国亮
徐靖
王瑛
李明焱
李振皓
ZHAO Jianxia;LI Zhenyu;ZHANG Guoliang;XU Jing;WANG Ying;LI Mingyan;LI Zhenhao(Zhejiang ShouXianGu Botanical Drug Institute Co.,Ltd.,Hangzhou 310000,China;Zhejiang ShouXianGu Pharmaceutical Co.,Ltd.,Wuyi 321200,China;Zhejiang Engineering Research Center of Rare Medicinal Plant,Wuyi 321200,China;Zhejiang Key Agricultural Enterprise Institute of ShouXianGu Rare Herb Products,Wuyi 321200,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2021年第12期1416-1425,共10页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81803714)
浙江省重点研发计划项目(2017C02011,2019C02100)
浙江省重点农业企业研究院建设项目(2017Y20001)。
关键词
CITESPACE
知识图谱分析
药理药效
物质基础
灵芝孢子粉
CiteSpace
knowledge mapping analysis
pharmacological efficacy
material basis
Ganoderma lucidum spore powder
作者简介
赵建霞,女,硕士,Tel:15657195620,E-mail:zhaojx@sxgoo.com;通信作者:李振皓,男,博士,副研究员,Tel:(0571)89189897,E-mail:zhenhao6@126.com。
