摘要
脑胶质瘤是颅内最常见的原发性恶性肿瘤,死亡率极高.目前针对脑胶质瘤的治疗手段预后差,难以实现良好的治疗效果.基于高分子聚合物的纳米药物以其良好的生物相容性、便于设计合成、易于靶向修饰以及较高的血脑屏障穿透效率等特性为脑胶质瘤的治疗开辟了新思路.基于高分子聚合物的纳米载体通过包载或键合等方式与小分子抗癌药物、核酸(DNA,siRNA)、蛋白质等治疗类物质结合提高抗肿瘤效果.本文综述了近年来对脑胶质瘤采用的化学治疗、基因治疗、免疫治疗、协同治疗等多种治疗方式及刺激响应性聚合物纳米载体的研究进展,并对其未来发展进行了展望.
Glioblastoma(GBM) is the most common primary malignant tumor with high mortality. Currently, the treatment for GBM displays poor prognosis which is difficult to achieve a satisfied therapeutic effect. Nanomedicines based on polymers have opened up new strategies for GBM therapy due to their unique features such as good biocompability, easy designation and synthesis, feasible ligand functionalization, efficient blood brain barrier(BBB) penetration. Polymeric nanocarriers boost efficient antitumor efficacy via encapsulate/conjugate therapeutics including small molecule anticancer drugs, nucleic acids(DNA, si RNA) and proteins. Here, we review the research progress of chemotherapy, gene therapy, immunotherapy, synergistic therapy as well as various stimuli responsive polymeric nanosystems for GBM over recent years, and also prospect for their future development.
作者
孙雅静
王一斌
刘艳杰
邹艳
郑蒙
师冰洋
SUN YaJing;WANG YiBin;LIU YanJie;ZOU Yan;ZHENG Meng;SHI BingYang(International Joint Center for Biomedical Innovation,School of Life Sciences,Henan University,Kaifeng 475004,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2021年第7期819-835,共17页
Scientia Sinica(Vitae)
关键词
聚合物
纳米药物
脑胶质瘤
治疗方式
polymer
nanomedicine
glioblastoma(GBM)
therapy methods
作者简介
联系人:师冰洋,E-mail:bs@henu.edu.cn;联系人:邹艳,yzou@henu.edu.cn。
