摘要
目的了解近年来有关胃癌早期诊断相关标志物的研究进展。方法查阅近年来国内外有关胃癌早期诊断标志物相关研究的文献并进行综述。结果目前由于胃癌血清肿瘤标志物如CEA和CA19-9的敏感性及特异性较低,因此,对可以在早期阶段预测、筛查和诊断胃癌的分子标志物进行了进一步的探索,结果发现,微小RNA、长链非编码RNA、环状RNA、外泌体等分子标志物在胃癌的早期诊断方面具有良好的临床应用前景。结论随着分子生物学技术的不断发展,必将进一步发掘微小RNA、长链非编码RNA、环状RNA、DNA等在胃癌早期诊断方面的价值。
Objective To understand the research progress of related biomarkers in early diagnosis of gastric cancer in recent years.Method The domestic and foregin literatures on studies of biomarkers of early diagnosis of gastric cancer in recent years were reviewed.Results At present,the sensitivity and specificity of serum tumor biomarkers of gastric cancer such as CEA and CA19-9 were lower,so the molecular markers that could predict,screen,and diagnose gastric cancer in the early stage were further explored.The recent studies suggested that microRNAs,long non-coding RNAs,circular RNAs,exosome,etc.molecular markers in early diagnosis of gastric cancer had better prospects of clinilal application.Conclusion With the continuous development of molecular biology technology,the values of microRNAs,long non-coding RNAs,circular RNAs,DNA,etc.in early diagnosis of gastric cancer would be further explored.
作者
吕海冰
戴志成
邹小明
LV Haibing;DAI Zhicheng;ZOU Xiaoming(Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2021年第8期1108-1113,共6页
Chinese Journal of Bases and Clinics In General Surgery
作者简介
通信作者:邹小明,Email:zou4930@163.com。
