摘要
1例44岁男性因发作性意识不清伴左上肢麻木、抽搐入院。脑电图提示左侧各导棘波频发,影像学检查提示右侧顶颞叶局部脑回肿胀、强化,脑脊液、血清样本提示抗N-甲基-D-天冬氨酸受体(NMDAR)抗体和抗髓鞘少突胶质细胞糖蛋白(MOG)抗体阳性,诊断为抗NMDAR抗体合并抗MOG抗体双阳性脑炎。予以免疫球蛋白、糖皮质激素联合奥卡西平治疗,随访5个月未见明显症状发作。临床报道该类双抗体阳性脑炎患者多为儿童,成年较罕见,及时诊断治疗患者可以取得良好的临床预后。
A 44-year-old male was admitted with paroxysm unconsciousness accompanying by numbness and convulsions in the left upper limb.EEG showed frequent spike waves on the left side,imaging examination showed swelling and enhancement of the local cerebral gyrus in the right parietal and temporal lobe,and cerebrospinal fluid and serum samples showed positive anti-N-methyl-D-aspartic acid receptor antibody(NMDAR)and anti-myelin oligodendrocyte glycoprotein(MOG)antibody.The diagnosis was anti-NMDAR antibody combined with anti-MOG antibody double positive encephalitis.The patients were treated with immunoglobulin,glucocorticoid combined with oxcarbazepine,and no obvious symptoms were observed during the 5-month follow-up.It has been clinically reported that patients with this type of double-antibody positive encephalitis are mostly seen in children,and it is rare in adults.Patients with timely diagnosis and treatment can achieve good clinical prognosis.
作者
徐义君
符长标
梁景岩
唐铁钰
王英歌
XU Yijun;FU Changbiao;LIANG Jingyan;TANG Tieyu;WANG Yingge(Department of Neurology,Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu,225000;Medical College of Yangzhou University,Yangzhou,Jiangsu,225000)
出处
《实用临床医药杂志》
CAS
2021年第11期47-49,53,共4页
Journal of Clinical Medicine in Practice
基金
国家重点研发计划(2016YFE0126000)
扬州大学附属医院新技术(省级)项目(2019-03)。
作者简介
通信作者:王英歌,E-mail:yingggewang279@hotmail.com。
