摘要
近年来,抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎及髓鞘少突胶质细胞糖蛋白(MOG)抗体相关疾病在同一患者体内同时或先后出现的报道逐渐增多,学者们将这类疾病统称为MOG抗体病及抗NMDAR脑炎重叠综合征(MNOS)。MNOS在临床表现、治疗、预后等方面不同于单纯的抗NMDAR脑炎或MOG抗体病,但因缺乏认识,临床医师往往容易忽视患者的一些临床表现,将这类综合征诊断为单纯的抗NMDAR脑炎或MOG抗体病,以致延误病情,影响预后。为加强对MNOS的认识,该文从MNOS的病因假说、发病人群特征、临床表现、影像学表现、疾病进程中的抗体特征、治疗方法等方面进行综述,以期为今后对该疾病的诊断及治疗提供参考。
In recent years,there have been increasing reports of anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis and myelin oligodendrocyte glycoprotein-antibody disease(MOG-Ab disease)appearing simultaneously or sequentially in the same patient.Some scholars have collectively referred to this kind of disease as the overlapping syndrome of MOG-Ab disease and anti-NMDAR encephalitis(MNOS).The clinical manifestations,treatment and prognosis of these syndromes are different from simple anti-NMDAR encephalitis or MOG-Ab disease.However,due to lack of understanding,clinicians tend to diagnose these syndromes as simple anti-NMDAR encephalitis or MOG-Ab disease,resulting in delayed the disease and affected prognosis.In order to strengthen the understanding of MNOS,this paper reviews MNOS from etiological hypothesis,characteristics of affected population,clinical manifestations,imaging manifestations,antibody characteristics in disease progression and treatment,so as to provide reference for the diagnosis and treatment in the future.
作者
何亚玲
沈雪阳
葛朝明
He Ya-Ling;Shen Xue-Yang;Ge Zhao-Ming(Department of Neurology,the Second Hospital of Lanzhou University/Clinical Research Center of Neurology of Gansu Province/Key Laboratory of Neurology of Gansu Province,Lanzhou 730030,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第12期1263-1267,共5页
Medical Journal of Chinese People's Liberation Army
作者简介
何亚玲,硕士研究生,主要从事神经免疫方面的研究;通信作者:葛朝明,E-mail:13893285120@163.com。
