摘要
目的观察葡萄糖酸钙锌口服液联合布拉酵母菌散剂对轮状病毒感染患儿症状控制及胃肠功能的影响,为临床治疗提供参考。方法选取2017年8月-2019年10月三亚市人民医院收治的120例轮状病毒感染患儿作为研究对象,根据治疗方法分为常规组与联合组,各60例,其中常规组给予饮食指导、合理补液、抗病毒、预防或纠正电解质紊乱等常规治疗,联合组在常规组治疗基础上给予葡萄糖酸钙锌口服液联合布拉酵母菌散剂治疗。记录2组患儿治疗前后粪便标本中肠道菌群含量、血清中胃肠激素水平变化,并统计分析2组患儿临床治疗总有效率、症状改善时间(退热、止泻、止吐、大便性状正常)及住院时间。结果治疗后,联合组总有效率为93.33%,高于常规组的80.00%(P <0.05),退热时间[(1.69±0.42)d]、止泻时间[(2.28±0.45)d]、止吐时间[(1.92±0.44)d]、大便性状正常时间[(2.30±0.45)d]、住院时间[(4.82±1.37)d]均短于常规组,差异均有统计学意义(P均<0.05)。治疗前,2组粪便标本中肠道菌群含量、血清中胃肠激素水平比较,差异均无统计学意义(P均> 0.05)。治疗后,2组粪便标本中双歧杆菌、乳酸杆菌含量较治疗前上升,肠杆菌含量及血清中胃泌素、胃动素、血管活性肠肽水平较治疗前下降,且联合组粪便标本中肠道菌群含量改善程度及胃肠激素水平下降幅度均高于常规组(P均<0.05)。结论葡萄糖酸钙锌口服液联合布拉酵母菌散剂可促进轮状病毒感染患儿临床症状的消失,改善胃肠激素水平,平衡肠道菌群,提高疗效。
Objective To observe the effect of calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets on symptom control and gastrointestinal function in children with rotavirus infection, and to provide reference for clinical treatment. Methods From August 2017 to October 2019, 120 children with rotavirus infection were selected from Sanya People’s Hospital, as the study subjects. According to the treatment methods, they were divided into conventional group and combined group, with 60 cases in each. The conventional group was treated with diet guidance, reasonable fluid rehydration, antiviral therapy and electrolyte disturbance prevention or correction therapy. The combined group was treated with calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets, in addition to conventional treatment in conventional group. The changes of intestinal flora content and serum levels of gastrointestinal hormones in fecal samples before and after treatment were recorded, and the overall response rate,symptom improvement time(antipyretic, anti-diarrhea, anti-vomiting, normal stool traits) and hospitalization time of children in 2 groups were statistically analyzed. Results After treatment, the overall response rate of the combined group was 93.33%, which was higher than that of the conventional group 80.00%(P <0.05). The antipyretic time [(1.69±0.42) d], anti-diarrhea time [(2.28±0.45) d], anti-vomiting time [(1.92±0.44) d], time to restore normal stool traits [(2.30±0.45) d], hospitalization time [(4.82±1.37) d] in the combined group were shorter than those in the conventional group, and the difference was statistically significant(P <0.05). Before treatment, there was no significant difference in intestinal flora content and serum levels of gastrointestinal hormones in fecal samples between 2 groups(P >0.05). After treatment, the contents of bifidobacteria and lactobacilli in the fecal samples of 2 groups increased compared with those before treatment, and the contents of enterobacteria and serum gastrin, motilin, and vascularly active intestinal peptides decreased compared with those before treatment, and the improvement of intestinal flora content in fecal samples and the decline of gastrointestinal hormones of the combined group were greater than that of the conventional group(P <0.05). Conclusions Calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets can promote the disappearance of clinical symptoms, improve the level of gastrointestinal hormone, balance intestinal flora and improve the curative effect in children with rotavirus infection.
作者
吴用
孙冕
黄淑芹
林容
WU Yong;SUN Mian;HUANG Shu-qin;LIN Rong(Department of Pediatrics,Sanya People’s Hospital,572000,China)
出处
《传染病信息》
2021年第4期320-323,346,共5页
Infectious Disease Information
基金
海南省重点科技计划项目(ZDXM20120055)。
关键词
葡萄糖酸钙锌口服液
布拉氏酵母菌散剂
轮状病毒感染
胃肠激素
肠道菌群
腹泻
疗效
calcium and zinc gluconate oral liquid
Saccharomyces boulardii sachets
rotavirus infection
gastrointestinal hormones
intestinal flora
diarrhea
curative effect
作者简介
通信作者:吴用,E-mail:277352021@qq.com。
