摘要
目的分析尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)联合血清胱抑素C(CysC)预测急性肾损伤(AKI)合并急性心力衰竭患者临床病情严重度的有效性。方法选取我院2018年3月至2020年3月期间收治的AKI合并急性心力衰竭患者200例,将患者分为AKI组(n=80)和非AKI组(n=120),其中AKI组包括轻症AKI组和重症AKI组,比较每组患者的NGAL、CysC、血肌酐(Scr)水平,探究尿NGAL联合血清CysC对AKI合并急性心力衰竭患者的临床病情严重度的预测效果。结果轻症AKI组患者的尿NGAL、CysC显著高于非AKI组,差异有统计学意义(P<0.05),轻症AKI组Scr与非AKI组比较,差异无统计学意义(P>0.05),重症AKI组患者的Scr浓度、尿NGAL、CysC显著高于非AKI组以及轻症AKI组相关指标(P<0.05)。NGAL(OR=2.028,95%CI=1.028~2.964)、CysC(OR=3.291,95%CI=1.419~3.281)均可作为AKI患者死亡的独立预测因素,联合应用(OR=8.361,95%CI=4.763~13.993)预测效果更佳。结论尿NGAL联合血清Cys C可以准确有效的预测肾损伤合并急性心力衰竭患者的临床情况,值得临床推广。
Objective To analyze the validity of urinary neutrophil gelatinase-associated lipocalin(NGAL)combined with serum cystatin C(CysC)in predicting the clinical severity of patients with acute kidney injury(AKI)combined with acute heart failure.Methods A total of 200 patients with kidney injury combined with acute heart failure admitted to our hospital from March 2018 to March 2020 were selected and divided into the AKI group(n=80)and the non-AKI group(n=120).The AKI group included the mild AKI group and the severe AKI group.The NGAL,CysC,and serum creatinine(Scr)levels in each group were compared to investigate the predictive effect of urinary NGAL combined with serum CysC on the clinical severity of patients with AKI combined with acute heart failure.Results The urinary NGAL and serum CysC of patients in the mild AKI group were significantly higher than those in the non-AKI group(P<0.05).There was no significant difference in Scr of patients in the mild AKI group and that in the non-AKI group(P>0.05).The Scr concentration,urinary NGAL,and CysC in the severe AKI group were significantly higher than those in the non-AKI group and the mild AKI group(P<0.05).NGAL(OR=2.028,95%CI=1.028-2.964)and CysC(OR=3.291,95%CI=1.419-3.281)could be used as independent predictors of the death of patients with AKI,and the combination of them(OR=8.361,95%CI=4.763-13.993)could achieve a better predicative effect.Conclusion Urinary NGAL combined with serum CysC can accurately and effectively predict the clinical condition of patients with kidney injury combined with acute heart failure,which is worthy of clinical promotion.
作者
莫荣浩
李梅
麦洁俭
刘成彬
MO Ronghao;LI Mei;MAI Jiejian;LIU Chengbin(Coronary Care Unit,the People's Hospital of Gaozhou,Guangdong,Gaozhou 525200,China)
出处
《中国医药科学》
2021年第13期203-205,225,共4页
China Medicine And Pharmacy
基金
广东省茂名市科技计划立项项目(2018147)。
关键词
尿NGAL
血清CYSC
肾损伤合并急性心力衰竭
血肌酐
Urinary neutrophil gelatinase-associated lipocalin
Serum cystatin C
Kidney injury combined with acute heart failure
Serum creatinine
