摘要
目的:观察银杏达莫联合丁苯酞及瑞替普酶治疗急性脑梗死的临床疗效。方法:将急性脑梗死患者120例采用随机数字表法分为两组各60例,对照组采用丁苯酞联合瑞替普酶治疗,治疗组在对照组基础上加用银杏达莫治疗,7天为1个疗程,两个疗程后观察两组患者临床疗效,检测治疗前后两组患者血清C反应蛋白(C-reaction protein,CRP)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malonaldehyde,MDA)、一氧化氮(nitric oxide,NO),血浆组织纤维蛋白溶解酶原激活剂(tissue-type plaminogen activator,t-PA)、1型纤维蛋白溶解酶原激活抑制剂(plasminogen activator inhibitor-1,PAI-1)水平,评估两组患者神经功能缺损评分(national institute of health stroke scale,NIHSS)及日常生活能力评分(activities of daily living,ADL)。结果:总有效率治疗组为91.7%(55/60),优于对照组的83.3%(50/60),差异有统计学意义(P<0.05)。两组治疗后CRP、TNF-α、IL-1β、MDA、PAI-1水平及NIHSS评分较治疗前降低,SOD、NO、t-PA水平及ADL评分较治疗前升高,治疗组各项指标改善程度优于对照组,差异均有统计学意义(P<0.05)。结论:银杏达莫联合丁苯酞及瑞替普酶能减轻急性脑梗死患者炎症反应,调节血浆纤维蛋白溶解系统功能,清除体内氧自由基及提高抗氧化酶活性,能恢复患者的神经功能,提高其日常生活能力,改善患者生活质量,效果优于丁苯酞联合瑞替普酶。
Objective:To observe clinical effects of ginkgo leaf extract and dipyridamole injection,butylphthalide and reteplase in treating acute cerebral infarction(ACI).Methods:All 120 patients were allocated to two groups according to random number table method,60 cases each group,the control group were treated by butylphthalide and reteplase,the treatment group by ginkgo leaf extract and dipyridamole injection based on the therapty the control group accepted,seven days were one course,to observe clinical effects in both groups after two courses,to detect the levels of CRP,TNF-α,IL-1β,SOD,MDA,NO,t-PA and PAI-1 before and after treating between both groups,to assess NIHSS scores and ADL scores between both groups.Results:Total effective rate of the treatment group was 91.7%(55/60),superior to 83.3%(50/60)of the control group,and the difference had statistical meaning(P<0.05).The levels of CRP,TNF-α,IL-1β,MDA,PAI-1 and NIHSS scores of both groups after treating reduced than before treating,the levels of SOD,NO and t-PA and ADL scores rose compared with these before treating,and the improvements of different indexes of the treatment group were superior to these of the control group,and the difference had statistical meaning(P<0.05).Conclusion:Ginkgo leaf extract and dipyridamole injection,butylphthalide and reteplase could relieve inflammatory reaction in ACI patients,regulate the function of plasma fibrinolysis system,eliminate oxygen free radicals in vivo and enhance the activity of antioxidant enzyme,help the recovery of neurological function,lift ADL,improve quality of life in patients,and its effects superior to these of butylphthalide and reteplase.
作者
刘华
崔秀卿
邢金梅
时岩
LIU Hua;CUI Xiuqing;XING Jinmei;SHI Yan(Anguo City Hospital,Baoding 071200,China;Baoding City the Second Hospital)
出处
《西部中医药》
2021年第7期98-101,共4页
Western Journal of Traditional Chinese Medicine
基金
保定市科技计划项目(18ZF016)。
作者简介
刘华(1984-),女,主治医师。研究方向:脑血管病的中西医结合防治。
