摘要
Lung cancer is the leading cause of cancer mortality worldwide.Dendritic cells(DCs)are the key factors providing protective immunity against lung tumors and clinical trials have proven that DC function is reduced in lung cancer patients.It is evident that the immunoregulatory network may play a key role in the failure of the immune response to terminate tumors.Lung tumors likely employ numerous strategies to suppress DC-based anti-tumor immunity.Here,we summarize the recent advances in our understanding on lung tumor-induced immunosuppression in DCs,which affects the initiation and development of T-cell responses.We also describe which existing measures to restore DC function may be useful for clinical treatment of lung tumors.Furthering our knowledge of how lung cancer cells alter DC function to generate a tumor-supportive environment will be essential in order to guide the design of new immunotherapy strategies for clinical use.
基金
This work was supported by the National Natural Science Foundation of China(No.81502589)
the Natural Science Foundation of Guangdong(No.408140352062 and 2014A030310481)
the Science and Technology Project of Shenzhen(CXZZ20130515092016300 and JCYJ20160422142707177)
the China Postdoctoral Science Foundation(No.2018M631046).
作者简介
Correspondence:Fu-Rong Li,frli62@163.com。
