摘要
生物体内的次氯酸是氯离子和过氧化氢(H2O2)由髓过氧化物酶(MPO)催化生成的,是生物体内最重要的活性氧(ROS)之一,在生理过程中发挥了至关重要的作用。但是,过量的次氯酸会导致一系列生理疾病,因此有效的识别和检测次氯酸备受研究者们的青睐。与传统检测方法相比,荧光探针具有选择性好、灵敏度高、可实时监测等诸多优势,因此在近年来得到了快速发展。本文主要基于不同的荧光团,综述了近三年次氯酸荧光探针的研究进展及生物应用。
Hypochlorous acid in organisms is produced from the reaction between chloride ions and hydrogen peroxide(H2O2)catalyzed by myeloperoxidase(MPO).It is one of the most important reactive oxygen species(ROS)in organisms and plays a vital role in physiological processes.However,excessive hypochlorite can lead to a series of physiological diseases,so the effective identification and detection of hypochlorite is favored by researchers.Compared with traditional detection methods,fluorescent probes have many advantages,such as good selectivity,high sensitivity and real-time monitoring,so they have been developed rapidly in recent years.In this paper,based on different fluorophores,the research progress and biological application of hypochlorite fluorescent probes in the last three years are reviewed.
作者
任春平
聂雯
冷俊强
刘振波
Chunping Ren;Wen Nie;Junqiang Leng;Zhenbo Liu(College of Chemistry and Chemical Engineering,Yantai University,Yantai 264005,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2021年第6期942-957,共16页
Progress in Chemistry
基金
山东省自然科学基金项目(No.ZR2019QB017)
烟台大学2020年研究生科技创新基金项目(No.YDYB2010)资助。
关键词
次氯酸
荧光探针
识别
检测
hypochlorous acid
fluorescent probe
recognition
detection
作者简介
Corresponding author:刘振波,e-mail:zhenboliu@foxmail.com。
