摘要
过敏性紫癜(Henoch-Sch?nlein purpura,HSP),又称为免疫球蛋白A血管炎,是最常见的儿童血管炎,可累及皮肤、胃肠道、关节和肾脏,糖皮质激素为合并消化系统症状的HSP的常规治疗方案。鉴于糖皮质激素的不良反应,临床上常联合抑酸剂治疗,包括H 2受体拮抗剂和质子泵抑制剂。抑酸剂可能通过缓解消化道症状、辅助治疗HSP继发性急性胰腺炎、抑制幽门螺杆菌、减轻激素不良反应对HSP发挥治疗作用。但目前研究较少,仍需进一步探索。
Henoch Schonlein purpura(HSP),also known as immunoglobulin A vasculitis,is the most common vasculitis in children,which involves skin,gastrointestinal tract,joints and kidney.Glucocorticoid is the conventional treatment for HSP patients with digestive system symptoms.Antacids,including H2-receptor antagonists and proton pump inhibitors,are often used in combination with glucocorticoids in order to avoid the adverse reactions of glucocorticoids therapy.Antacids may play a role in the treatment of HSP patients by alleviating gastrointestinal symptoms,adjuvant treatment of secondary acute pancreatitis,inhibiting Helicobacter pylori and reducing the adverse reactions of glucocorticoids.However,there are few studies and more exploration is needed.
作者
李婧
毛志芹
Li Jing;Mao Zhiqin(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中国小儿急救医学》
CAS
2021年第6期529-531,共3页
Chinese Pediatric Emergency Medicine
关键词
过敏性紫癜
H
2受体拮抗剂
质子泵抑制剂
抑酸剂
Henoch Schonlein purpura
H2-receptor antagonists
Proton pump inhibitors
Antacids
作者简介
通信作者:毛志芹,Email:maozq@sj-hospital.org。
